Cytochrome P4502C is an EDHF synthase in coronary arteries

被引：29

作者：

Fleming, I ^{[1
]}

机构：

[1] Univ Frankfurt Klinikum, Inst Kardiovask Physiol, D-60590 Frankfurt, Germany

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2000年 / 10卷 / 04期

关键词：

D O I：

10.1016/S1050-1738(00)00065-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Studies designed to elucidate the identity of the potent vasodilator autacoid endothelium-derived hyperpolarizing factor (EDHF) in the coronary vascular bed have highlighted a role for vascular cytochrome P450 (CYP) enzymes in cardiovascular homeostasis. Not only is there strong evidence suggesting that the putative coronary EDHF synthase is an endothelially expressed CYP epoxygenase, but CYP products such as epoxyeicosatrienoic acids and reactive oxygen species have been implicated in the regulation of intracellular signalling cascades and vascular cell proliferation. (Trends Cardiovasc Med 2000;10:166-170). (C) 2001, Elsevier Science Inc. All rights reserved.

引用

页码：166 / 170

页数：5

共 40 条

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