The role of FGF/Erk signaling in pluripotent cells

被引：303

作者：

Lanner, Fredrik ^{[1
]}

Rossant, Janet ^{[1
,2
]}

机构：

[1] Hosp Sick Children, Res Inst, Program Dev & Stem Cell Biol, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada

来源：

DEVELOPMENT | 2010年 / 137卷 / 20期

基金：

瑞典研究理事会;

关键词：

FGF signaling; Stem cells; Embryonic development; EMBRYONIC STEM-CELLS; ACTIVATED PROTEIN-KINASE; SELF-RENEWAL; PRIMITIVE ENDODERM; GENE-EXPRESSION; MOUSE EPIBLAST; TARGETED DISRUPTION; GROUND-STATE; MAP KINASE; GROWTH;

D O I：

10.1242/dev.050146

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fibroblast growth factor (FGF) signaling controls fundamental processes such as proliferation, differentiation and migration throughout mammalian development. Here we discuss recent discoveries that implicate FGF/Erk signaling in the control of pluripotency and lineage specification in several different stem cell states, including the separation of pluripotent epiblast and primitive endoderm in the blastocyst, the lineage priming of embryonic stem (ES) cells, and in the stabilization of the metastable state of mouse epiblast and human ES cells. Understanding how extrinsic signals such as FGF regulate different stem cell states will be crucial to harvest the clinical promise of induced pluripotent and embryo-derived stem cells.

引用

页码：3351 / 3360

页数：10

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