New trimethoprim-resistant dihydrofolate reductase cassette, dfrXV, inserted in a class 1 integron

被引：17

作者：

Adrian, PV

du Plessis, M

Klugman, KP

Amyes, SGB

机构：

[1] S African Inst Med Res, Dept Med Microbiol, ZA-2000 Johannesburg, South Africa

[2] Univ Witwatersrand, Dept Med Microbiol, Johannesburg, South Africa

[3] Univ Edinburgh, Dept Med Microbiol, Edinburgh, Midlothian, Scotland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 09期

关键词：

D O I：

10.1128/AAC.42.9.2221

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The nucleotide sequence of a plasmid-borne trimethoprim resistance gene from a commensal fecal Escherichia coli isolate revealed a new dihydrofolate reductase gene, dfrXV, which occurred as a gene cassette integrated in a site-specific manner in a class 1 integron. The new gene shows 84% nucleotide identity and the predicted protein shows 90% amino acid identity with dfrI and DHFR type I, respectively. Genes for spectinomycin resistance, aadA1 [ant (3 ")-Ia], and sulfonamide resistance, sul1, were located downstream of dfrXV in a manner identical to that in pLMO229.

引用

页码：2221 / 2224

页数：4

共 31 条

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