Phosphoinositide 3-kinases in T lymphocyte activation

被引：82

作者：

Ward, SG

Cantrell, DA

机构：

[1] Imperial Canc Res Fund, Lymphocyte Activat Lab, London WC2A 3PX, England

[2] Univ Bath, Dept Pharmacol, Bath BA2 7AY, Avon, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(00)00223-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Biochemical experiments have established that the metabolism of inositol phospholipids by phosphoinositide 3-kinases (PI3Ks) and lipid-phosphatases is triggered by many receptors that control T lymphocyte function, including antigen-receptors, costimulatory molecules, cytokines and chemokines. Novel effectors of PI3K have been identified in the immune system and shown to be important in the control of lymphocyte activation. Moreover, key lipid-phosphatases have been identified that act to terminate or modulate PI3K signalling in cells of the immune system.

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页码：332 / 338

页数：7

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