Phosphoinositide 3-kinases in T lymphocyte activation

被引:82
作者
Ward, SG
Cantrell, DA
机构
[1] Imperial Canc Res Fund, Lymphocyte Activat Lab, London WC2A 3PX, England
[2] Univ Bath, Dept Pharmacol, Bath BA2 7AY, Avon, England
关键词
D O I
10.1016/S0952-7915(00)00223-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Biochemical experiments have established that the metabolism of inositol phospholipids by phosphoinositide 3-kinases (PI3Ks) and lipid-phosphatases is triggered by many receptors that control T lymphocyte function, including antigen-receptors, costimulatory molecules, cytokines and chemokines. Novel effectors of PI3K have been identified in the immune system and shown to be important in the control of lymphocyte activation. Moreover, key lipid-phosphatases have been identified that act to terminate or modulate PI3K signalling in cells of the immune system.
引用
收藏
页码:332 / 338
页数:7
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