Lignans from Schisandra hernyi with DNA cleaving activity and cytotoxic effect on leukemia and Hela cells in vitro

被引：23

作者：

Chen, YG ^{[1
]}

Wu, ZC

Gui, SH

Lv, YP

Liao, XR

Halaweish, F

机构：

[1] Yunnan Normal Univ, Dept Chem, Kunming 650092, Yunnan, Peoples R China

[2] Yunnan Inst Tradit Chinese Med, Dept Tradit Chinese Herbs, Kunming 650011, Peoples R China

[3] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA

来源：

FITOTERAPIA | 2005年 / 76卷 / 3-4期

基金：

中国国家自然科学基金;

关键词：

Schisandra henryi; lignans; cytotoxic activity;

D O I：

10.1016/j.fitote.2005.03.012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The lignans, gomisin G (1), schisantherin A (2), benzoylgomisin Q (3) and isoanwulignan (4) were isolated from the stems of Schisandra henryi. Compound I showed moderate DNA strand scission activity and significant cytotoxic effect on leukemia and Hela cells in vitro. Compound I represents a new type of DNA strand scission agent. (c) 2005 Published by Elsevier B.V.

引用

页码：370 / 373

页数：4

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