Rational approaches to the design of cationic gemini surfactants for gene delivery

被引：171

作者：

McGregor, C

Perrin, C

Monck, M

Camilleri, P

Kirby, AJ

机构：

[1] SmithKline Beecham Pharmaceut, Harlow CM19 5AW, Essex, England

[2] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

[3] SmithKline Beecham Pharmaceut, Collegeville, PA 19426 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2001年 / 123卷 / 26期

关键词：

D O I：

10.1021/ja005681c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a new class of amphiphilic gemini surfactants as vehicles for gene delivery into cells, and the beginnings of a systematic structure-activity study. Preliminary results suggest that combining gemini surfactants with dioleoylphosphatidylethanolamine (DOPE) should allow the preparation of liposomes of various sizes and lipid compositions. Control of such colloidal changes could be as significant as the changes in the molecular composition of the gemini surfactants in delivering optimum gene expression in animal models.

引用

页码：6215 / 6220

页数：6

共 9 条

[1] A novel class of cationic gemini surfactants showing efficient in vitro gene transfection properties [J].