Genome sequence of a serotype m28 strain of group A Streptococcus:: Potential new insights into puerperal sepsis and bacterial disease specificity

被引:187
作者
Green, NM
Zhang, SZ
Porcella, SF
Nagiec, MJ
Barbian, KD
Beres, SB
LeFebvre, RB
Musser, JM
机构
[1] Baylor Coll Med, Ctr Human Bacterial Pathogenesis Res, Dept Pathol, Houston, TX 77030 USA
[2] NIAID, Lab Human Bacterial Pathogenesis, Rocky Mt Labs, NIH, Hamilton, MT USA
[3] Univ Calif Davis, Dept Pathol Microbiol & Immunol, Davis, CA 95616 USA
关键词
D O I
10.1086/430618
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Puerperal sepsis, a major cause of death of young women in Europe in the 1800s, was due predominantly to the gram-positive pathogen group A Streptococcus. Studies conducted during past decades have shown that serotype M28 strains are the major group A Streptococcus organisms responsible for many of these infections. To begin to increase our understanding of their enrichment in puerperal sepsis, we sequenced the genome of a genetically representative strain. This strain has genes encoding a novel array of prophage virulence factors, cell-surface proteins, and other molecules likely to contribute to host-pathogen interactions. Importantly, genes for 7 inferred extracellular proteins are encoded by a 37.4-kb foreign DNA element that is shared with group B Streptococcus and is present in all serotype M28 strains. Proteins encoded by the 37.4-kb element were expressed extracellularly and in human infections. Acquisition of foreign genes has helped create a disease-specialist clone of this pathogen.
引用
收藏
页码:760 / 770
页数:11
相关论文
共 73 条
[1]   Short-course antibiotic treatment of 4782 culture-proven cases of group A streptococcal tonsillopharyngitis and incidence of poststreptococcal sequelae [J].
Adam, D ;
Scholz, H ;
Helmerking, M .
JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (02) :509-516
[2]   Progress toward characterization of the group a Streptococcus metagenome:: Complete genome sequence of a macrolide-resistant serotype M6 strain [J].
Banks, DJ ;
Porcella, SF ;
Barbian, KD ;
Beres, SB ;
Philips, LE ;
Voyich, JM ;
DeLeo, FR ;
Martin, JM ;
Somerville, GA ;
Musser, JM .
JOURNAL OF INFECTIOUS DISEASES, 2004, 190 (04) :727-738
[3]   Structure and distribution of an unusual chimeric genetic element encoding macrolide resistance in phylogenetically diverse clones of group A Streptococcus [J].
Banks, DJ ;
Porcella, SF ;
Barbian, KD ;
Martin, JM ;
Musser, JM .
JOURNAL OF INFECTIOUS DISEASES, 2003, 188 (12) :1898-1908
[4]   Prophage induction and expression of prophage-encoded virulence factors in group A Streptococcus serotype M3 strain MGAS315 [J].
Banks, DJ ;
Lei, BF ;
Musser, JM .
INFECTION AND IMMUNITY, 2003, 71 (12) :7079-7086
[5]   The fundamental contribution of phages to GAS evolution, genome diversification and strain emergence [J].
Banks, DJ ;
Beres, SB ;
Musser, JM .
TRENDS IN MICROBIOLOGY, 2002, 10 (11) :515-521
[6]   The CHAP domain: a large family of amidases including GSP amidase and peptidoglycan hydrolases [J].
Bateman, A ;
Rawlings, ND .
TRENDS IN BIOCHEMICAL SCIENCES, 2003, 28 (05) :234-237
[7]   Genome-wide molecular dissection of serotype M3 group A Streptococcus strains causing two epidemics of invasive infections [J].
Beres, SB ;
Sylva, GL ;
Sturdevant, DE ;
Granville, CN ;
Liu, MY ;
Ricklefs, SM ;
Whitney, AR ;
Parkins, LD ;
Hoe, NP ;
Adams, GJ ;
Low, DE ;
DeLeo, FR ;
McGeer, A ;
Musser, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (32) :11833-11838
[8]   Genome sequence of a serotype M3 strain of group A Streptococcus:: Phage-encoded toxins, the high-virulence phenotype, and clone emergence [J].
Beres, SB ;
Sylva, GL ;
Barbian, KD ;
Lei, BF ;
Hoff, JS ;
Mammarella, ND ;
Liu, MY ;
Smoot, JC ;
Porcella, SF ;
Parkins, LD ;
Campbell, DS ;
Smith, TM ;
McCormick, JK ;
Leung, DYM ;
Schlievert, PM ;
Musser, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) :10078-10083
[9]   Molecular basis of group A streptococcal virulence [J].
Bisno, AL ;
Brito, MO ;
Collins, CM .
LANCET INFECTIOUS DISEASES, 2003, 3 (04) :191-200
[10]   Current concepts - Streptococcal infections of skin and soft tissues [J].
Bisno, AL ;
Stevens, DL .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (04) :240-245