Protozoan genomics for drug discovery

被引：53

作者：

Chaudhary, K

Roos, DS

机构：

[1] Univ Penn, Dept Biol, Penn Genom Inst, Philadelphia, PA 19104 USA

[2] Univ Penn, MVP Grad Program, Philadelphia, PA 19104 USA

来源：

NATURE BIOTECHNOLOGY | 2005年 / 23卷 / 09期

关键词：

D O I：

10.1038/nbt0905-1089

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Comparing the metabolic pathways of parasites and their hosts facilitates the identification of new drug targets.

引用

页码：1089 / 1091

页数：3

共 35 条

[1] Complete genome sequence of the apicomplexan, Cryptosporidium parvum [J].

Abrahamsen, MS ;

Templeton, TJ ;

Enomoto, S ;

Abrahante, JE ;

Zhu, G ;

Lancto, CA ;

Deng, MQ ;

Liu, C ;

Widmer, G ;

Tzipori, S ;

Buck, GA ;

Xu, P ;

Bankier, AT ;

Dear, PH ;

Konfortov, BA ;

Spriggs, HF ;

Iyer, L ;

Anantharaman, V ;

Aravind, L ;

Kapur, V .

SCIENCE, 2004, 304 (5669) :441-445

[2] The genome of the African trypanosome Trypanosoma brucei [J].

Berriman, M ;

Ghedin, E ;

Hertz-Fowler, C ;

Blandin, G ;

Renauld, H ;

Bartholomeu, DC ;

Lennard, NJ ;

Caler, E ;

Hamlin, NE ;

Haas, B ;

Böhme, W ;

Hannick, L ;

Aslett, MA ;

Shallom, J ;

Marcello, L ;

Hou, LH ;

Wickstead, B ;

Alsmark, UCM ;

Arrowsmith, C ;

Atkin, RJ ;

Barron, AJ ;

Bringaud, F ;

Brooks, K ;

Carrington, M ;

Cherevach, I ;

Chillingworth, TJ ;

Churcher, C ;

Clark, LN ;

Corton, CH ;

Cronin, A ;

Davies, RM ;

Doggett, J ;

Djikeng, A ;

Feldblyum, T ;

Field, MC ;

Fraser, A ;

Goodhead, I ;

Hance, Z ;

Harper, D ;

Harris, BR ;

Hauser, H ;

Hostetter, J ;

Ivens, A ;

Jagels, K ;

Johnson, D ;

Johnson, J ;

Jones, K ;

Kerhornou, AX ;

Koo, H ;

Larke, N .

SCIENCE, 2005, 309 (5733) :416-422

[3] Protozomics: Trypanosomatid parasite genetics comes of age [J].

Beverley, SM .

NATURE REVIEWS GENETICS, 2003, 4 (01) :11-19

[4] GENOME SEQUENCES - A MICROBIAL MINIMALIST [J].

BLOOM, BR .

NATURE, 1995, 378 (6554) :236-236

[5] Fosmidomycin-clindamycin for the treatment of Plasmodium falciparum malaria [J].

Borrmann, S ;

Issifou, S ;

Esser, G ;

Adegnika, AA ;

Ramharter, M ;

Matsiegui, PB ;

Oyakhirome, S ;

Mawili-Mboumba, DP ;

Missinou, MA ;

Kun, JFJ ;

Jomaa, H ;

Kremsner, PG .

JOURNAL OF INFECTIOUS DISEASES, 2004, 190 (09) :1534-1540

[6] Antigenic variation and allelic exclusion [J].

Borst, P .

CELL, 2002, 109 (01) :5-8

[7] Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii [J].

Carlton, JM ;

Angiuoli, SV ;

Suh, BB ;

Kooij, TW ;

Pertea, M ;

Silva, JC ;

Ermolaeva, MD ;

Allen, JE ;

Selengut, JD ;

Koo, HL ;

Peterson, JD ;

Pop, M ;

Kosack, DS ;

Shumway, MF ;

Bidwell, SL ;

Shallom, SJ ;

van Aken, SE ;

Riedmuller, SB ;

Feldblyum, TV ;

Cho, JK ;

Quackenbush, J ;

Sedegah, M ;

Shoaibi, A ;

Cummings, LM ;

Florens, L ;

Yates, JR ;

Raine, JD ;

Sinden, RE ;

Harris, MA ;

Cunningham, DA ;

Preiser, PR ;

Bergman, LW ;

Vaidya, AB ;

Van Lin, LH ;

Janse, CJ ;

Waters, AP ;

Smith, HO ;

White, OR ;

Salzberg, SL ;

Venter, JC ;

Fraser, CM ;

Hoffman, SL ;

Gardner, MJ ;

Carucci, DJ .

NATURE, 2002, 419 (6906) :512-519

[8] Manipulating the Plasmodium genome [J].

Carvalho, TG ;

Ménard, R .

CURRENT ISSUES IN MOLECULAR BIOLOGY, 2005, 7 :39-55

[9] Molecules on the surface of the Plasmodium falciparum infected erythrocyte and their role in malaria pathogenesis and immune evasion [J].

Craig, A ;

Scherf, A .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2001, 115 (02) :129-143

[10] The strategies of the Theileria parasite:: a new twist in host-pathogen interactions [J].

Dobbelaere, DAE ;

Küenzi, P .

CURRENT OPINION IN IMMUNOLOGY, 2004, 16 (04) :524-530

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