Statistical investigation into the structural complementarity of natural products and synthetic compounds

被引：76

作者：

Henkel, T

Brunne, RM

Müller, H

Reichel, F

机构：

[1] Bayer AG, Pharma Forsch, Life Sci Ctr Nat Prod PH R LSC NP, D-42096 Wuppertal, Germany

[2] Bayer AG, Zent Forsch Wirkstofforsch ZF WFM, D-42096 Wuppertal, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1999年 / 38卷 / 05期

关键词：

drug research; molecular diversity; natural products; statistical analysis; structural properties;

D O I：

10.1002/(SICI)1521-3773(19990301)38:5<643::AID-ANIE643>3.0.CO;2-G

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

The potential of new natural products as an important source for the exploration and development of new drugs and crop protection products is a long way from being exhausted. The statistical analysis of the structures of the natural and synthetically derived compounds has shown conspicuous variations in structural types in the natural products derived from different natural sources, which can be utilized in the search for individual active substances. The occasionally voiced prepossession that natural products have already been sufficiently examined and therefore no more innovations are to be expected can definitely be rejected.

引用

页码：643 / 647

页数：5