Influence of surgical margins on local recurrence in T1/T2 oral squamous cell carcinoma

被引：42

作者：

Barry, Conor P. ^{[1
]}

Ahmed, Ferhan ^{[1
]}

Rogers, Simon N. ^{[1
,2
]}

Lowe, Derek ^{[2
]}

Bekiroglu, Fazilet ^{[1
]}

Brown, James S. ^{[1
]}

Shaw, Richard J. ^{[1
,3
]}

机构：

[1] Aintree Univ Hosp NHS Fdn Trust, Head & Neck Unit, Liverpool L9 7AL, Merseyside, England

[2] Edge Hill Univ, Fac Hlth, Evidence Based Practice Res Ctr EPRC, Ormskirk, England

[3] Univ Liverpool, Dept Surg & Oncol, Sch Canc Studies, Liverpool L69 3BX, Merseyside, England

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2015年 / 37卷 / 08期

关键词：

oral cancer; recurrence; survival; margins; nodal metastases; postoperative radiotherapy; NECK DISSECTION; CANCER PATIENTS; ELECTIVE NECK; SURVIVAL; SURGERY; TONGUE; RISK; METAANALYSIS; RESECTION; CAVITY;

D O I：

10.1002/hed.23729

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 [耳鼻咽喉科学];

摘要：

BackgroundThe purpose of this study was to explore the significance of resection margin status on local recurrence and survival for early (T1/T2) oral cancer and to determine if the significance of the resection margin varies with the biological aggression of the tumor as determined by pN status. MethodsThe influence of resection margin size and local recurrence for 295 patients with pT1/T2 oral cavity squamous cell carcinomas (SCCs) treated by primary surgery, including neck dissection, between 1998 and 2010 was analyzed. ResultsOverall, there was a trend toward increased local recurrence with close or involved margins. When stratified according to nodal status, there was no relationship between margin size and local recurrence for the pN0 group. ConclusionThe size of the resection margin does not seem to influence local control in stage I/II oral cancer. With future advances in preoperative neck staging, this data may help plan personalized therapy in head and neck cancer. (c) 2014 Wiley Periodicals, Inc. Head Neck37: 1176-1180, 2015

引用

页码：1176 / 1180

页数：5

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