Clinicopathological implications of NQO1 overexpression in the prognosis of pancreatic adenocarcinoma

被引：20

作者：

Ji, Meiying ^{[1
,2
]}

Jin, Aihua ^{[3
]}

Sun, Jie ^{[1
,2
]}

Cui, Xuelian ^{[1
,2
]}

Yang, Yang ^{[1
,2
]}

Chen, Liyan ^{[1
,2
,4
]}

Lin, Zhenhua ^{[1
,2
]}

机构：

[1] Yanbian Univ, Canc Res Ctr, Med Coll, 977 Gongyuan Rd, Yanji 133002, Jilin, Peoples R China

[2] Yanbian Univ, Dept Pathol, Med Coll, 977 Gongyuan Rd, Yanji 133002, Jilin, Peoples R China

[3] Yanbian Univ Hosp, Dept Internal Med, Yanji 133000, Jilin, Peoples R China

[4] Yanbian Univ, Med Coll, Dept Biol Chem & Mol Biol, Yanji 133002, Jilin, Peoples R China

来源：

ONCOLOGY LETTERS | 2017年 / 13卷 / 05期

基金：

中国国家自然科学基金;

关键词：

pancreatic ductal adenocarcinoma; NQO1; immunohistochemistry; prognosis; survival analysis; OXIDOREDUCTASE; 1; POOR-PROGNOSIS; EXPRESSION;

D O I：

10.3892/ol.2017.5821

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase 1 (NQO1) protects cells from oxidative damage. NQO1 has been reported to be upregulated in numerous solid tumors, suggesting a role in carcinogenesis and tumor progression. The present study attempted to investigate the clinical prognostic significance of NQO1 overexpression in pancreatic ductal adenocarcinoma (PDAC). A total of 181 tissue specimens were studied, including 126 PDAC and 55 normal pancreas specimens, which were selected for immunohistochemical staining of NQO1 protein. Immunofluorescence staining was additionally performed to identify the subcellular localization of NQO1 protein in pancreatic cancer BxPC-3 cells. The association between NQO1 overexpression and the clinical features of PDAC were evaluated by chi(2) and Fisher's exact test. Overall survival of PDAC patients was calculated using Kaplan-Meier analysis. Univariate and multivariate analyses were performed using the Cox proportional hazards regression model. The NQO1 protein was mainly located in the cytoplasm and nucleus of BxPC-3 cells. The strongly positive rate of NQO1 expression in PDAC (65.9%, 83/126) was increased compared with that in normal pancreatic tissues (10.9%, 6/55). The positive rate of NQO1 protein was associated with grading, lymph node stage and tumor-node-metastasis (TNM) stage. Additionally, multivariate analysis suggested that NQO1 was a significant independent prognostic factor along with TNM stage in PDAC. In conclusion, high expression of NQO1 appears to be associated with PDAC progression, and may be an independent prognostic biomarker in PDAC.

引用

页码：2996 / 3002

页数：7

共 28 条

[1]

Bosman FT, 2010, WHO Classification of tumors of the digestive system, V4th

[2]

NQO1 Expression Correlates with Cholangiocarcinoma Prognosis [J].