Proinflammatory cytokines but not acute phase serum amyloid A or C-reactive protein, downregulate paraoxonase 1 (PON1) expression by HepG2 cells

被引：56

作者：

Kumon, Y ^{[1
]}

Nakauchi, Y

Suehiro, T

Shiinoki, T

Tanimoto, N

Inoue, M

Nakamura, T

Hashimoto, K

Sipe, JD

机构：

[1] Kochi Med Sch, Dept Internal Med 2, Nanko Ku, Kochi 7838505, Japan

[2] NIH, Ctr Sci Review, IRG, Bethesda, MD 20892 USA

来源：

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS | 2002年 / 9卷 / 03期

关键词：

atherosclerosis; inflammation; cytokine; HDL;

D O I：

10.3109/13506120209114817

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression of paraoxonase(1) (PON1) during inflammation has been investigated in vitro. The alteration of steady state PON1 mRNA in HepG2 cells by interleukin-1,8 (IL-1) and tumor necrosis factor-alpha (TNF-alpha), was investigated relative to acute-phase serum amyloid A (A-SAA) mRNA. PON1 mRNA expression by HepG2 cells was decreased within three hours of stimulation by IL-1beta or TNFalpha. Relative to PON1 mRNA expression, the pattern of steady state A-SAA mRNA expression was altered reciprocally and inversely by IL- 1beta. These findings suggested that the decrease in serum PON activity after abdominal surgery in our previous clinical study may he ascribed to a decrease in steady state PON1 mRNA expression by liver with proinflammatory cytokines.

引用

页码：160 / 164

页数：5

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