Mouse hepatitis virus does not induce beta interferon synthesis and does not inhibit its induction by double-stranded RNA

被引：92

作者：

Zhou, Haixia ^{[1
]}

Perlman, Stanley ^{[1
]}

机构：

[1] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA

来源：

JOURNAL OF VIROLOGY | 2007年 / 81卷 / 02期

关键词：

D O I：

10.1128/JVI.01512-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mouse hepatitis virus (MHV) does not induce interferon (IFN) production in fibroblasts or bone marrow-derived dendritic cells. In this report, we show that the essential IFN-beta transcription factors NF-kappa B and IFN regulatory factor 3 are not activated for nuclear translocation and gene induction during infection. However, MHV was unable to inhibit the activation of these factors and subsequent IFN-beta production induced by poly(I:C). Further, MHV infection did not inhibit IFN-beta production mediated by known host pattern recognition receptors (PRRs) (RIG-I, Mda-5, and TLR3). These results are consistent with the notion that double-stranded RNA, produced during MHV infection, is not accessible to cellular PRRs.

引用

收藏

页码：568 / 574

页数：7

相关论文

共 63 条

[1] Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].

Alexopoulou, L ;

Holt, AC ;

Medzhitov, R ;

Flavell, RA .

NATURE, 2001, 413 (6857) :732-738

[2] The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-β promoter [J].

Andrejeva, J ;

Childs, KS ;

Young, DF ;

Carlos, TS ;

Stock, N ;

Goodbourn, S ;

Randall, RE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (49) :17264-17269

[3] Differential activation of interferon regulatory factors-3 and-7 by non-cytopathogenic and cytopathogenic bovine viral diarrhoea virus [J].

Baigent, SJ ;

Goodbourn, S ;

McCauley, JW .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2004, 100 (3-4) :135-144

[4] Inhibition of beta interferon transcription by noncytopathogenic bovine viral diarrhea virus is through an interferon regulatory factor 3-dependent mechanism [J].

Baigent, SJ ;

Zhang, G ;

Fray, MD ;

Flick-Smith, H ;

Goodbourn, S ;

McCauley, JW .

JOURNAL OF VIROLOGY, 2002, 76 (18) :8979-8988

[5] Murine coronavirus replication-induced p38 mitogen-activated protein kinase activation promotes interleukin-6 production and virus replication in cultured cells [J].

Banerjee, S ;

Narayanan, K ;

Mizutani, T ;

Makino, S .

JOURNAL OF VIROLOGY, 2002, 76 (12) :5937-5948

[6] The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3 [J].

Basler, CF ;

Mikulasova, A ;

Martinez-Sobrido, L ;

Paragas, J ;

Mühlberger, E ;

Bray, M ;

Klenk, HD ;

Palese, P ;

García-Sastre, A .

JOURNAL OF VIROLOGY, 2003, 77 (14) :7945-7956

[7]

CERVANTESBARRAG.L, 2006, BLOOD 0910

[8] Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis [J].

Cheung, CY ;

Poon, LLM ;

Ng, IHY ;

Luk, W ;

Sia, SF ;

Wu, MHS ;

Chan, KH ;

Yuen, KY ;

Gordon, S ;

Guan, Y ;

Peiris, JSM .

JOURNAL OF VIROLOGY, 2005, 79 (12) :7819-7826

[9] The glycosylation status of the murine hepatitis coronavirus M protein affects the interferogenic capacity of the virus in vitro and its ability to replicate in the liver but not the brain [J].

de Haan, CAM ;

de Wit, M ;

Kuo, L ;

Montalto-Morrison, C ;

Haagmans, BL ;

Weiss, SR ;

Masters, PS ;

Rottier, PJM .

VIROLOGY, 2003, 312 (02) :395-406

[10] CELL TROPISM AND EXPRESSION OF MOUSE HEPATITIS VIRUSES (MHV) IN MOUSE SPINAL-CORD CULTURES [J].

DUBOISDALCQ, ME ;

DOLLER, EW ;

HASPEL, MV ;

HOLMES, KV .

VIROLOGY, 1982, 119 (02) :317-331

← 1 2 3 4 5 6 7 →