Short-term rivastigmine treatment reduces EEG slow-wave power in Alzheimer patients

被引：56

作者：

Adler, G ^{[1
]}

Brassen, S ^{[1
]}

机构：

[1] Cent Inst Mental Hlth, Day Clin Elderly & Clin Neurophysiol Serv, D-6800 Mannheim, Germany

来源：

NEUROPSYCHOBIOLOGY | 2001年 / 43卷 / 04期

关键词：

EEG; dementia; Alzheimer's disease; therapy; acetylcholinesterase inhibitor; rivastigmine;

D O I：

10.1159/000054902

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of a 5-day treatment with rivastigmine on the resting EEG power spectrum were studied in 15 mildly to moderately ill Alzheimer patients. In these patients, beta power was positively correlated with cognitive performance and negatively correlated with functional impairment. Rivastigmine produced a decrease in delta and theta power with no effect of hemisphere and electrode position. Delta power decrease reflects the cerebral cholinergic action of rivastigmine and may thus allow a quantitative assessment of its CNS effects. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：273 / 276

页数：4

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