Expanding the Optical Trapping Range of Lipid Vesicles to the Nanoscale

被引：47

作者：

Bendix, Poul M. ^{[1
]}

Oddershede, Lene B. ^{[1
]}

机构：

[1] Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark

来源：

NANO LETTERS | 2011年 / 11卷 / 12期

关键词：

Optical trapping; lipid vesicles; liposomes; nanoparticles; force spectroscopy; position detection; GOLD NANOPARTICLES; POSITION DETECTION; RAMAN MICROSCOPY; SINGLE-MOLECULE; TWEEZERS; MICROTUBULE; PARTICLES; MEMBRANES;

D O I：

10.1021/nl203200g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Small unilamellar lipid vesicles with diameters down to 50 nm enclosing high refractive index sucrose cores can be optically trapped individually in three dimensions using a focused laser beam. Combined optical trapping and confocal microscopy allows for simultaneous quantitative measurements of the forces exerted on individual vesicles and of their size and shape. The position of individual vesicles in three dimensions is measured with nanometer spatial and similar to 10 mu s temporal resolution.

引用

收藏

页码：5431 / 5437

页数：7

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