The recent origins of spliceosomal introns revisited

被引:162
作者
Logsdon, JM [1 ]
机构
[1] Dalhousie Univ, Dept Biochem, Halifax, NS B3H 4H7, Canada
关键词
D O I
10.1016/S0959-437X(98)80031-2
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Does the intron/exon structure of eukaryotic genes belie their ancient assembly by exon-shuffling or have introns been inserted into preformed genes during eukaryotic evolution? These are the central questions in the ongoing 'introns-early' versus 'introns-late' controversy. The phylogenetic distribution of spliceosomal introns continues to strongly favor the inirons-late theory. The introns-early theory, however, has claimed support from intron phase and protein structure correlations.
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页码:637 / 648
页数:12
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