The ins and outs of transcriptional control: nucleocytoplasmic shuttling in development and disease

被引：59

作者：

Smith, JM

Koopman, PA ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

[2] Univ Queensland, Australian Res Council Ctr Excellence Biotechnol, Brisbane, Qld 4072, Australia

来源：

TRENDS IN GENETICS | 2004年 / 20卷 / 01期

关键词：

D O I：

10.1016/j.tig.2003.11.007

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent findings relating to SOX transcription factors indicate that defects in organogenesis can be caused not only by impairment of the biochemical properties of transcription factors but also, in some cases, by deficient nuclear import. In addition, experimentally interfering with the nuclear export signals of some SOX factors has now been found to cause developmental defects. Controlling the balance of nuclear import and export might be a common means by which transcription factor activity can be regulated during development, and defects in these processes might underlie a broader spectrum of inherited developmental disorders.

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页码：4 / 8

页数：5

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