Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction (Review)

被引：46

作者：

Kikuchi, Kiyoshi ^{[2
]}

Kawahara, Ko-Ichi ^{[1
]}

Uchikado, Hisaaki

Miyagi, Naohisa ^{[2
]}

Kuramoto, Terukazu ^{[10
]}

Miyagi, Tomoya ^{[10
]}

Morimoto, Yoko ^{[5
]}

Ito, Takashi ^{[1
]}

Tancharoen, Salunya ^{[11
]}

Miura, Naoki ^{[6
,7
]}

Takenouchi, Kazunori ^{[1
]}

Oyama, Yoko ^{[1
]}

Shrestha, Binita ^{[1
]}

Matsuda, Fumiyo ^{[8
]}

Yoshida, Yoshihiro ^{[8
]}

Arimura, Shinihiro ^{[3
]}

Mera, Kentaro ^{[4
]}

Tada, Ko-Ichi ^{[4
]}

Yoshinaga, Narimasa ^{[1
]}

Maenosono, Ryuichi ^{[1
]}

Ohno, Yoshiko ^{[1
]}

Hashiguchi, Teruto ^{[1
]}

Maruyama, Ikuro ^{[1
]}

Shigemori, Minoru ^{[9
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Field Cardiovasc & Resp Disorders, Div Lab & Vasc Med,Dept Adv Therapeut, Kagoshima 8908520, Japan

[2] Yame Publ Gen Hosp, Dept Neurosurg, Yame 8340034, Japan

[3] Kagoshima Univ, Grad Sch Med & Dent Sci, Field Oral & Maxillofacial Rehabil, Dept Maxillofacial Diagnost & Surg Sci, Kagoshima 8908520, Japan

[4] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Dermatol, Kagoshima 8908520, Japan

[5] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Restorat Dent & Endodontol, Kagoshima 8908544, Japan

[6] Kagoshima Univ, Fac Agr, Vet Teaching Hosp, Kagoshima 8900065, Japan

[7] Kagoshima Univ, Fac Agr, Lab Vet Diagnost Imaging, Kagoshima 8900065, Japan

[8] Kagoshima Univ, Fac Med, Sch Hlth Sci, Div Phys Therapy, Kagoshima 8908506, Japan

[9] Kurume Univ, Sch Med, Dept Neurosurg, Kurume, Fukuoka 8300011, Japan

[10] Omuta City Gen Hosp, Dept Neurosurg, Fukuoka 8368567, Japan

[11] Mahidol Univ, Fac Dent, Dept Pharmacol, Bangkok 10400, Thailand

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2011年 / 2卷 / 05期

关键词：

edaravone; cerebral infarction; free radical scavenger; neuroprotection; neurologic disease; FREE-RADICAL SCAVENGER; CU/ZN SUPEROXIDE-DISMUTASE; TRAUMATIC BRAIN-INJURY; SPINAL-CORD-INJURY; CRANIAL IRRADIATION; ISCHEMIC-STROKE; MCI-186; CELLS; DAMAGE; DIFFERENTIATION;

D O I：

10.3892/etm.2011.281

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Edaravone was originally developed as a potent free radical scavenger and has been widely used to treat cerebral infarction in Japan since 2001. Several free radical scavengers have been developed and some of them have progressed to clinical trials for the treatment of cerebral infarction. One such scavenger, edaravone, has been approved by the regulatory authority in Japan for the treatment of patients with cerebral infarction. Of particular interest is the ability of edaravone to diffuse into the central nervous system in various neurologic diseases. Aside from its hydroxyl radical scavenging effect, edaravone has been found to have beneficial effects on inflammation, matrix metalloproteinases, nitric oxide production and apoptotic cell death. Concordantly, edaravone has been found to have neuroprotective effects in a number of animal models of disease, including stroke, spinal cord injury, traumatic brain injury, neurodegenerative diseases and brain tumors. The proven safety of edaravone following 9 years of use as a free radical scavenger suggests that it may have potential for development into an effective treatment of multiple neurologic conditions in humans.

引用

页码：771 / 775

页数：5

共 60 条

[1] Guidelines for the early management of adults with ischemic stroke - A guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the atherosclerotic peripheral vascular disease and quality of care outcomes in research interdisciplinary working groups
Adams, Harold P., Jr.
del Zoppo, Gregory
Alberts, Mark J.
Bhatt, Deepak L.
Brass, Lawrence
Furlan, Anthony
Grubb, Robert L.
Higashida, Randall T.
Jauch, Edward C.
Kidwell, Chelsea
Lyden, Patrick D.
Morgenstern, Lewis B.
Qureshi, Adnan I.
Rosenwasser, Robert H.
Scott, Phillip A.
Wijdicks, Eelco F. M.
[J]. STROKE, 2007, 38 (05) : 1655 - 1711
[2] Anderson VA, 2000, BRIT J CANCER, V82, P255
[3] High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes
Andersson, U
Wang, HC
Palmblad, K
Aveberger, AC
Bloom, O
Erlandsson-Harris, H
Janson, A
Kokkola, R
Zhang, MH
Yang, H
Tracey, KJ
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (04) : 565 - 570
[4] Combined transplantation of neural stem cells and olfactory ensheathing cells for the repair of spinal cord injuries
Ao, Q.
Wang, A. J.
Chen, G. Q.
Wang, S. J.
Zuo, H. C.
Zhang, X. F.
[J]. MEDICAL HYPOTHESES, 2007, 69 (06) : 1234 - 1237
[5] Reactive oxygen species modulate growth of cerebral aneurysms: a study using the free radical scavenger edaravone and p47phox-/- mice
Aoki, Tomohiro
Nishimura, Masaki
Kataoka, Hiroharu
Ishibashi, Ryota
Nozaki, Kazuhiko
Hashimoto, Nobuo
[J]. LABORATORY INVESTIGATION, 2009, 89 (07) : 730 - 741
[6] Edaravone (MCI-186) Scavenges Reactive Oxygen Species and Ameliorates Tissue Damage in the Murine Spinal Cord Injury Model
Aoyama, Takeshi
Hida, Kazutoshi
Kuroda, Satoshi
Seki, Toshitaka
Yano, Shunsuke
Shichinohe, Hideo
Iwasaki, Yoshinobu
[J]. NEUROLOGIA MEDICO-CHIRURGICA, 2008, 48 (12) : 539 - 545
[7] Traumatic brain injury induced cell proliferation in the adult mammalian central nervous system
Chirumamilla, S
Sun, D
Bullock, MR
Colello, RJ
[J]. JOURNAL OF NEUROTRAUMA, 2002, 19 (06) : 693 - 703
[8] Cohen JA, 2009, ARCH NEUROL-CHICAGO, V66, P821, DOI 10.1001/archneurol.2009.104
[9] NEUROBEHAVIORAL SEQUELAE OF CRANIAL IRRADIATION IN ADULTS - A REVIEW OF RADIATION-INDUCED ENCEPHALOPATHY
CROSSEN, JR
GARWOOD, D
GLATSTEIN, E
NEUWELT, EA
[J]. JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (03) : 627 - 642
[10] Epidemiology of Parkinson's disease
de Lau, Lonneke M. L.
Breteler, Monique M. B.
[J]. LANCET NEUROLOGY, 2006, 5 (06) : 525 - 535

← 1 2 3 4 5 6 →