Non-alcoholic fatty liver disease and insulin resistance

被引：79

作者：

Machado, M ^{[1
]}

Cortez-Pinto, H ^{[1
]}

机构：

[1] Univ Hosp Santa Maria, Dept Gastroenterol, Ctr Nutr & Metab, Lisbon, Portugal

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 2005年 / 17卷 / 08期

关键词：

non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; insulin resistance; metabolic syndrome; obesity;

D O I：

10.1097/00042737-200508000-00008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Non-alcoholic fatty liver disease (NAFLD) is an entity now recognized as one of the leading causes of asymptomatic chronic elevation of aminotransferase levels, which can, however, progress to more advanced forms of hepatic lesion and ultimately to liver failure. Insulin resistance is considered as having a central role in NAFLD pathogenesis, which is related with oxidative stress, abnormal production of cytokines and deregulation of fatty acid metabolism. In this article the authors make a brief review of the epidemiological data about NAFLD and insulin resistance, and their aetiological link, and treatment implications.

引用

页码：823 / 826

页数：4

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