Anti-apoptotic effects of melatonin in retinal pigment epithelial cells

被引：23

作者：

Fu, Yang ^{[1
]}

Tang, Min ^{[1
]}

Fan, Ying ^{[1
]}

Zou, Haidong ^{[1
]}

Sun, Xiaodong ^{[1
]}

Xu, Xun ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 1, Dept Ophthalmol, Shanghai 200080, Peoples R China

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2012年 / 17卷

关键词：

Apoptosis; Melatonin; Retinal Pigment Epithelial Cell; MITOCHONDRIAL-DNA; OXIDATIVE STRESS; MACULAR DEGENERATION; ANTIOXIDANT ENZYMES; NUCLEAR-DNA; RECEPTOR; DAMAGE; BRAIN; LIGHT;

D O I：

10.2741/3997

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Recent studies have revealed that melatonin exerts strong anti-apoptotic effects. Retina secretes melatonin, and melatonin receptors are distributed in almost all the layers of retina, including the layer of retinal pigment epithelial (RPE) cells. However, it is not known whether melatonin inhibits apoptosis through its antioxidant effects and how it works in RPE cells. Here, we show that melatonin decreases H2O2-induced apoptosis in RPE cells partially through protection of mitochondria. Melatonin decreased reactive oxygen species in mitochondria and mitochondrial DNA damage, alleviated structural damage and inhibited cytochrome C release.

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页码：1461 / 1468

页数：8

相关论文

共 28 条

[1]

Barak A, 2001, INVEST OPHTH VIS SCI, V42, P247

[2]

The basic physiology and pathophysiology of melatonin [J].

Claustrat, B ;

Brun, J ;

Chazot, G .

SLEEP MEDICINE REVIEWS, 2005, 9 (01) :11-24

[3]

Molecular pathology of age-related macular degeneration [J].

Ding, Xiaoyan ;

Patel, Mrinali ;

Chan, Chi-Chao .

PROGRESS IN RETINAL AND EYE RESEARCH, 2009, 28 (01) :1-18

[4]

GROWTH OF CULTURED RPE AND ENDOTHELIAL-CELLS IS INHIBITED BY BLUE-LIGHT BUT NOT GREEN OR RED-LIGHT [J].

DOREY, CK ;

DELORI, FC ;

AKEO, K .

CURRENT EYE RESEARCH, 1990, 9 (06) :549-559

[5]

The role of apoptosis in age-related macular degeneration [J].

Dunaief, JL ;

Dentchev, T ;

Ying, GS ;

Milam, AH .

ARCHIVES OF OPHTHALMOLOGY, 2002, 120 (11) :1435-1442

[6]

Bcl-2 overexpression increases survival in human retinal pigment epithelial cells exposed to H2O2 [J].

Godley, BF ;

Jin, GF ;

Guo, YS ;

Hurst, JS .

EXPERIMENTAL EYE RESEARCH, 2002, 74 (06) :663-669

[7]

Reactions of the melatonin metabolite AMK (N1-acetyl-5-methoxykynuramine) with reactive nitrogen species:: Formation of novel compounds, 3-acetamidomethyl-6-methoxycinnolinone and 3-nitro-AMK [J].

Guenther, AL ;

Schmidt, SI ;

Laatsch, H ;

Fotso, S ;

Ness, H ;

Ressmeyer, AR ;

Poeggeler, B ;

Hardeland, R .

JOURNAL OF PINEAL RESEARCH, 2005, 39 (03) :251-260

[8]

Circadian clocks, clock networks, arylalkylarnine N-acetyltransferase, and melatonin in the retina [J].

Iuvone, PM ;

Tosini, G ;

Pozdeyev, N ;

Haque, R ;

Klein, DC ;

Chaurasia, SS .

PROGRESS IN RETINAL AND EYE RESEARCH, 2005, 24 (04) :433-456

[9]

Visualization of melatonin's multiple mitochondrial levels of protection against mitochondrial Ca2+-mediated permeability transition and beyond in rat brain astrocytes [J].

Jou, Mei-Jie ;

Peng, Tsung-I ;

Hsu, Lee-Fen ;

Jou, Shuo-Bin ;

Reiter, Russel J. ;

Yang, Chuen-Mao ;

Chiao, Chuan-Chin ;

Lin, Yi-Fan ;

Chen, Chun-Chia .

JOURNAL OF PINEAL RESEARCH, 2010, 48 (01) :20-38

[10]

Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes [J].

Jou, MJ ;

Peng, TI ;

Reiter, RJ ;

Jou, SB ;

Wu, HY ;

Wen, ST .

JOURNAL OF PINEAL RESEARCH, 2004, 37 (01) :55-70