Aromatase in the brain: Not just for reproduction anymore

被引：169

作者：

Garcia-Segura, L. M. ^{[1
]}

机构：

[1] CSIC, Inst Cajal, E-28002 Madrid, Spain

来源：

JOURNAL OF NEUROENDOCRINOLOGY | 2008年 / 20卷 / 06期

关键词：

behaviour; cognition; neurogenesis; neuroprotection; oestrogens; synaptic plasticity;

D O I：

10.1111/j.1365-2826.2008.01713.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aromatase, the enzyme that synthesises oestrogens from androgen precursors, is expressed in the brain, where it has been classically associated with the regulation of neuroendocrine events and behaviours linked with reproduction. Recent findings, however, have revealed new unexpected roles for brain aromatase, indicating that the enzyme regulates synaptic activity, synaptic plasticity, neurogenesis and the response of neural tissue to injury, and may contribute to control nonreproductive behaviours, mood and cognition. Therefore, the function of brain aromatase is not restricted to the regulation of reproduction as previously thought.

引用

收藏

页码：705 / 712

页数：8

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