Arrested DNA replication in Xenopus and release by Escherichia coli mutagenesis proteins

被引：13

作者：

Oda, N

Levin, JD

Spoonde, AY

Frank, EG

Levine, AS

Woodgate, R

Ackerman, EJ

机构：

[1] NIDDKD,NIH,BETHESDA,MD 20892

[2] NICHHD,SECT DNA REPLICAT REPAIR & MUTAGENESIS,NIH,BETHESDA,MD 20892

来源：

SCIENCE | 1996年 / 272卷 / 5268期

关键词：

D O I：

10.1126/science.272.5268.1644

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Xenopus oocytes and oocyte nuclear extracts repair ultraviolet photoproducts on double-stranded (ds) DNA and replicate single-stranded (ss) to ds DNA, M13 ss DNA molecules containing cyclobutane pyrimidine dimers were maintained but not replicated in Xenopus oocytes, yet were replicated in progesterone-matured oocytes, The replication arrest functioned only in cis, The replication arrest was alleviated by injection into oocytes of messenger RNAs encoding the prokaryotic mutagenesis proteins UmuD'C or MucA'B, These results may help explain how cells stabilize repair or replication events on DNA with unrepairable lesions.

引用

页码：1644 / 1646

页数：3

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