The retrosynthetic approach toward artificial nacre via amorphous precursor particles was discussed. Artificial nacre was synthesized by remineralization of the insoluble matrix of natural nacre after demineralization and removement of soluble proteins with 10% acetic acid via the gas diffusion method. As amorphous precursor particles were created in the excess solution phase, it was to be concluded that they migrate into the demineralized matrix to transform into the observed platelets. The results show that amorphous precursor particles are ideal candidate for effective storage, rapid transport, and buildup of mimicked biological minerals.