In Vitro Activity of Fosfomycin against blaKPC-Containing Klebsiella pneumoniae Isolates, Including Those Nonsusceptible to Tigecycline and/or Colistin

被引：125

作者：

Endimiani, Andrea ^{[1
,2
]}

Patel, Gopi ^{[3
]}

Hujer, Kristine M. ^{[1
,2
]}

Swaminathan, Mahesh ^{[3
]}

Perez, Federico ^{[1
,2
]}

Rice, Louis B. ^{[1
]}

Jacobs, Michael R. ^{[4
]}

Bonomo, Robert A. ^{[1
,2
,5
,6
]}

机构：

[1] Vet Affairs Med Ctr, Louis Stokes Cleveland Dept, Res Serv, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44106 USA

[3] Mt Sinai Sch Med, Dept Med, New York, NY USA

[4] Case Western Reserve Univ, Sch Med, Dept Pathol, Cleveland, OH 44106 USA

[5] Case Western Reserve Univ, Sch Med, Dept Pharmacol, Cleveland, OH 44106 USA

[6] Case Western Reserve Univ, Sch Med, Dept Mol Biol & Microbiol, Cleveland, OH 44106 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 01期

基金：

美国国家卫生研究院;

关键词：

MOLECULAR EPIDEMIOLOGY; URINARY-TRACT; POLYMYXIN-B; SUSCEPTIBILITY; RESISTANCE;

D O I：

10.1128/AAC.01235-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In vitro activity of fosfomycin was evaluated against 68 bla(KPC)-possessing Klebsiella pneumoniae (KpKPC) isolates, including 23 tigecycline- and/or colistin-nonsusceptible strains. By agar dilution, 93% of the overall KpKPC were susceptible (MIC50/90 of 16/64 mu g/ml, respectively). The subgroup of 23 tigecycline- and/or colistin-nonsusceptible strains showed susceptibility rates of 87% (MIC50/90 of 32/128 mu g/ml, respectively). Notably, 5 out of 6 extremely drug-resistant (tigecycline and colistin nonsusceptible) KpKPC were susceptible to fosfomycin. Compared to agar dilution, disk diffusion was more accurate than Etest.

引用

页码：526 / 529

页数：4

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