A novel and efficient synthesis of pyrimido[4,5-d]pyrimidine-2,4,7-trione and pyrido[2,3-d:6,5-d] dipyrimidine-2,4,6,8-tetrone derivatives

被引：125

作者：

Dabiri, Minoo ^{[1
]}

Arvin-Nezhad, Harnid ^{[1
]}

Khavasi, Hamid Reza ^{[1
]}

Bazgir, Ayoob ^{[1
]}

机构：

[1] Shahid Beheshti Univ, Dept Chem, Tehran 1983963113, Iran

来源：

TETRAHEDRON | 2007年 / 63卷 / 08期

关键词：

pyrimido[4,5-d]pyrimidine-trione; microwave; pyrido[2,3-d : 6,5-d]-dipyrimidine-2,4,6,8-tetrone; multi-component; SOLVENT-FREE CONDITIONS; ONE-POT SYNTHESIS; FACILE SYNTHESIS; MICROWAVE; INHIBITION; PYRIMIDINES; CYCLIZATION; RING;

D O I：

10.1016/j.tet.2006.12.043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and direct procedure for the synthesis of pyrimido[4,5-d]pyrimidine-2,4,7-trione derivatives has been described under microwave-assisted conditions. Reaction of 6-amino-1,3-dimethyluracil with aromatic aldehydes resulted in the formation of pyrido[2,346,5-d] dipyrimidine-2,4,6,8-tetrone derivatives. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1770 / 1774

页数：5

共 34 条

[1]

Bazgir A, 2006, J CHEM RES-S, P1

[2]

BERNIER JL, 1977, EUR J MED CHEM, V12, P341

[3] MICROWAVE-ASSISTED ORGANIC-REACTIONS [J].

CADDICK, S .

TETRAHEDRON, 1995, 51 (38) :10403-10432

[4] INHIBITION OF FERROUS-INDUCED LIPID-PEROXIDATION BY PYRIMIDO-PYRIMIDINE DERIVATIVES IN HUMAN LIVER MEMBRANES [J].

DELACRUZ, JP ;

CARRASCO, T ;

ORTEGA, G ;

DELACUESTA, FS .

LIPIDS, 1992, 27 (03) :192-194

[5]

Dömling A, 2000, ANGEW CHEM INT EDIT, V39, P3168, DOI 10.1002/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO

[6]

2-U

[7] SYNTHESIS OF 1,3,7,9-TETRAMETHYL-2,4,6,8-TETRAOXO-1,2,3,4,6,7,8,9-OCTAHYDROPYRIDO[2,3-D - 6,5-D']-DIPYRIMIINE FROM 6-AMINO-1,3-DIMETHYLURACIL AND DIMETHYL SULFOXIDE [J].

ELDERFIELD, RC ;

WHARMBY, M .

JOURNAL OF ORGANIC CHEMISTRY, 1967, 32 (05) :1638-+

[8]

FRY DW, 1995, MOL PHARMACOL, V47, P810

[9] Synthesis of quaternised 2-aminopyrimido[4,5-d]pyrimidin-4(3H)-ones and their biological activity with dihydrofolate reductase [J].

Gebauer, MG ;

McKinlay, C ;

Gready, JE .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2003, 38 (7-8) :719-728

[10] A facile microwave induced one-pot synthesis of novel pyrimido[4,5-d]pyrimidines and pyrido[2,3-d]pyrimidines under solvent-free conditions [J].

Gohain, M ;

Prajapati, D ;

Gogoi, BJ ;

Sandhu, JS .

SYNLETT, 2004, (07) :1179-1182

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