Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2

被引：774

作者：

Biragyn, A ^{[1
]}

Ruffini, PA

Leifer, CA

Klyushnenkova, E

Shakhov, A

Chertov, O

Shirakawa, AK

Farber, JM

Segal, DM

Oppenheim, JJ

Kwak, LW

机构：

[1] NCI, Expt Transplantat & Immunol Branch, Bethesda, MD 20892 USA

[2] NCI, Expt Immunol Branch, Bethesda, MD 20892 USA

[3] Sci Applicat Int Corp, Intramural Res Support Program, Frederick, MD 21702 USA

[4] Sci Applicat Int Corp, Prot Chem Lab, Frederick, MD 21702 USA

[5] NIAID, Clin Invest Lab, NIH, Bethesda, MD 20892 USA

[6] NCI, Mol Immunoregulat Lab, Frederick, MD 21702 USA

来源：

SCIENCE | 2002年 / 298卷 / 5595期

关键词：

D O I：

10.1126/science.1075565

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

beta-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. We demonstrate that murine beta-defensin 2 (mDF2beta) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and dendritic cell maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2beta may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens.

引用

页码：1025 / 1029

页数：6

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