The pilosebaceous unit: A pivotal route for topical drug delivery

被引：28

作者：

Agarwal, R

Katare, OP ^{[1
]}

Vyas, SP

机构：

[1] Panjab Univ, Inst Pharmaceut Sci, Chandigarh 160014, India

[2] HS Gour Univ, Dept Pharmaceut Sci, Sagar, India

来源：

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY | 2000年 / 22卷 / 02期

关键词：

topical application; pilosebaceous unit; hair follicle; liposome; phospholipid;

D O I：

10.1358/mf.2000.22.2.796082

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The hair follicle, hair shaft and sebaceous gland are collectively known as the pilosebaceous unit. The pilosebaceous unit is a complex, dynamic, 3-D structure, which is the site of unique biochemical, metabolical and immunological events. Ongoing research has focused on the hair follicle as a potential route for both localized and systemic drug delivery. Targeted drug delivery to the specific sites of hair follicle has paved ways to treat several dermatological abnormalities that are known to originate at the hair follicle. In recent studies, topical liposomes have been shown to target the drug to the pilosebaceous unit. This review describes general aspects of pilosebaceous unit, follicular delivery, with particular emphasis on studies which have demonstrated targeted follicular delivery via liposomes. (C) 2000 Prous Science. All rights reserved.

引用

页码：129 / 133

页数：5

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