A HCN-based reaction under microreactor conditions:: industrially feasible and continuous synthesis of 3,4-diamino-1H-isochromen-1-ones

被引：49

作者：

Acke, Davy R. J. ^{[1
]}

Stevens, Christian V. ^{[1
]}

机构：

[1] Univ Ghent, Fac Biosci Engn, Dept Organ Chem, Res Grp SynBioC, B-9000 Ghent, Belgium

来源：

GREEN CHEMISTRY | 2007年 / 9卷 / 04期

关键词：

D O I：

10.1039/b615186h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Microreactor technology has been studied as a suitable process to produce chemicals via multicomponent reactions. In this study, efforts were made to produce 3,4-diamino-1H- isochromen-1-ones. Based on a known reaction procedure, using in situ generated HCN, a safe reaction setup was created to avoid the release of the hazardous gas during the process. The 3,4-diamino-1H-isochromen-1-ones were produced continuously in moderate to good yields.

引用

页码：386 / 390

页数：5

共 47 条

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