Characterization of monoclonal antibodies against Hokkaido strain tick-borne encephalitis virus

被引：14

作者：

Komoro, K ^{[1
]}

Hayasaka, D ^{[1
]}

Mizutani, T ^{[1
]}

Kariwa, H ^{[1
]}

Takashima, I ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Vet Med, Dept Environm Vet Sci, Publ Hlth Lab,Kita Ku, Sapporo, Hokkaido 0600818, Japan

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2000年 / 44卷 / 06期

关键词：

tick-borne encephalitis virus; monoclonal antibodies; flavivirus;

D O I：

10.1111/j.1348-0421.2000.tb02530.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A tick-borne encephalitis (TBE) patient was found in Hokkaido in 1993, and TEE viruses were isolated from animals and ticks in our previous studies. To develop a diagnostic reagent to identify TBE viruses, monoclonal antibodies (Mabs) were produced against the TBE virus strain Hokkaido (Oshima 5-10), Seven Mabs were obtained which reacted with the envelope protein of the Oshima 5-10 strain. These Mabs were flavivirus genus-specific, TBE virus complex-specific or TEE virus type-specific. The Mabs are applicable for identification of TBE virus strains.

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收藏

页码：533 / 536

页数：4

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