Altered hemostasis in migraineurs studied with a dynamic flow system

被引:33
作者
Tietjen, Gretchen E. [1 ]
Al-Qasmi, Mohamed M. [1 ]
Athanas, Kathleen [1 ]
Utley, Christine [1 ]
Herial, Nabeel A. [1 ]
机构
[1] Med Univ Ohio, Dept Neurol, Toledo, OH 43614 USA
关键词
clot signature; analyzer; hemostasis; livedo reticularis; migraine; von Willebrand factor;
D O I
10.1016/j.thromres.2005.12.020
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Livedo reticularis (LR) refers to the violaceous netlike pattern of skin related to arteriopathy at the dermis-subcutis border. Livedo, is associated with migraine, and among migraineurs, LR is more common in those with prior stroke. Other evidence of vascular perturbation in migraine comes from studies showing elevated von Willebrand factor (vWF). The purpose of this study is to evaluate global hemostasis in migraineurs, including the subset with LR, using a dynamic flow system simulating physiological conditions, and measuring vWF activity and antigen levels. Materials and methods: Patients with migraine were enrolled from the headache clinic and presence or absence of LR was noted. Age-matched healthy, non-migraine, LR-free individuals were recruited as controls. To evaluate hemostasis, we used the Clot Signature Analyzer (CSA) measuring platelet hemostasis time (PHT), collagen-induced thrombus formation (CITF), and clot time (CT). vWF activity and vWF antigen levels were also measured. Results: The mean vWF activity level (142.7 vs. 103.4, p < 0.01) and antigen level (132.1 vs. 104.5, p < 0.05) were higher, and all three hemostasis parameters shorter in the episodic migraineurs than in the controls. The subset of migraineurs with LR had the highest vWF activity (155 +/- 59, p < 0.05) and vWF antigen (141 +/- 43, p < 0.05) levels, and the shortest PHT (3.7 +/- 1.6, p < 0.05). In this subset there was a significant inverse correlation between vWF activity and PHT (r = -0.51, p = 0.01). Conclusions: For migraineurs, the differences from controls in vWF and PHT are most robust in the LR subset, with the inverse correlation suggesting that endothetial perturbation may be causally related to the response of the platelets. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:217 / 222
页数:6
相关论文
共 28 条
[1]   INCREASED LEVELS OF PLASMA VON-WILLEBRAND-FACTOR IN MIGRAINE CRISIS [J].
CESAR, JM ;
GARCIAAVELLO, A ;
VECINO, AM ;
SASTRE, JL ;
ALVAREZCERMENO, JC .
ACTA NEUROLOGICA SCANDINAVICA, 1995, 91 (05) :412-413
[2]  
DANDREA G, 1982, HEADACHE, V22, P207
[3]   Prospective study of hemostatic factors and incidence of coronary heart disease - The Atherosclerosis Risk in Communities (ARIC) Study [J].
Folsom, AR ;
Wu, KK ;
Rosamond, WD ;
Sharrett, AR ;
Chambless, LE .
CIRCULATION, 1997, 96 (04) :1102-1108
[4]   Prospective study of markers of hemostatic function with risk of ischemic stroke [J].
Folsom, AR ;
Rosamond, WD ;
Shahar, E ;
Cooper, LS ;
Aleksic, N ;
Nieto, FJ ;
Rasmussen, ML ;
Wu, KK .
CIRCULATION, 1999, 100 (07) :736-742
[5]   A multicenter clinical evaluation of the Clot Signature Analyzer [J].
Fricke, W ;
Kouides, P ;
Kessler, C ;
Schmaier, AH ;
Krijanovski, Y ;
Jagadeesan, K ;
Joist, J .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2004, 2 (05) :763-768
[6]   Evidence for activation of the coagulation system in migraine with aura [J].
Hering-Hanit, R ;
Friedman, Z ;
Schlesinger, I ;
Ellis, M .
CEPHALALGIA, 2001, 21 (02) :137-139
[7]   Evaluation of the clot signature analyzer as a hemostasis test in healthy volunteers exposed to low doses of aspirin [J].
Igawa, T ;
Kornhauser, R ;
Cilla, DD ;
King, JO ;
Kambayashi, J .
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 1999, 5 (02) :117-121
[8]   THE PLATELET AND MIGRAINE - A NONSPECIFIC ASSOCIATION [J].
JOSEPH, R ;
WELCH, KMA .
HEADACHE, 1987, 27 (07) :375-380
[9]  
KALASHNIKOVA LA, 1994, KLIN MED MOSCOW+, V72, P29
[10]   COMPLICATED MIGRAINE ITS ASSOCIATION WITH INCREASED PLATELET AGGREGABILITY AND ABNORMAL PLASMA COAGULATION-FACTORS [J].
KALENDOVSKY, Z ;
AUSTIN, JH .
HEADACHE, 1975, 15 (01) :18-35