Anti-HIV ribozymes

被引：26

作者：

Sun, LQ ^{[1
]}

Ely, JA ^{[1
]}

Gerlach, W ^{[1
]}

Symonds, G ^{[1
]}

机构：

[1] JOHNSON & JOHNSON RES LABS,SYDNEY,NSW 2001,AUSTRALIA

来源：

MOLECULAR BIOTECHNOLOGY | 1997年 / 7卷 / 03期

关键词：

HIV; ribozyme; gene therapy; retrovirus;

D O I：

10.1007/BF02740815

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

HN is an RNA virus that replicates intracellularly through various RNA intermediates. Several Of these can be targeted by ribozymes (catalytic RNA molecules), and a number of investigators, including, this group, have demonstrated the ability of ribozymes to suppress HIV replication in this way. It is argued that this gene therapy approach may be viewed as an adjunct to chemotherapeutic drugs, which may allow not just viral suppression, but also immune restoration. This can only finally be tested in clinical trials, and several are planned. The basic ribozyme unit, the potential of which Was described less than 10 years ago, is about to be tested in an amenable disease state.

引用

页码：241 / 251

页数：11

共 82 条

[1]

AGUILARCORDOVA E, 1995, GENE THER, V2, P181

[2]

THE ENIGMA OF HIV-INFECTION - OVERVIEW [J].