Vitamin D and the Immune System

被引：119

作者：

Maruotti, Nicola ^{[1
]}

Cantatore, Francesco Paolo ^{[1
]}

机构：

[1] Univ Foggia, Sch Med, Dept Rheumatol, Foggia, Italy

来源：

JOURNAL OF RHEUMATOLOGY | 2010年 / 37卷 / 03期

关键词：

AUTOIMMUNITY; VITAMIN D; B LYMPHOCYTES; T LYMPHOCYTES; RECEPTOR GENE POLYMORPHISM; DENDRITIC CELL-DIFFERENTIATION; AUTOIMMUNE-DISEASE PREVALENCE; REGULATORY T-CELLS; 1,25-DIHYDROXYVITAMIN D-3; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; D DEFICIENCY; IN-VITRO; LUPUS-ERYTHEMATOSUS; HUMAN KERATINOCYTES;

D O I：

10.3899/jrheum.090797

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Evidence of the role of vitamin D in the regulation of T and B cells, macrophages, dendritic cells, and keratinocytes continues to accumulate and provides a link between vitamin D and many autoimmune diseases, including Crohn's disease, juvenile diabetes mellitus, Multiple sclerosis, asthma, and rheumatoid arthritis. Considering the influence of vitamin D oil the immune system, it may have potential as a treatment for immune-mediated diseases, even if additional research is required to better quantify dosage. But the biggest obstacle to its clinical use is its potent hypercalcemic effect. The calcium status of the host may influence the effect of vitamin D on immunity. (First Release Jan 15 20 10; J Rheumatol 2010;37:491-5; doi: 10.3899/jrheum.090797)

引用

页码：491 / 495

页数：5