Begin at the beginning: evolution of translational initiation

被引：28

作者：

Benelli, Dario ^{[1
]}

Londei, Paola ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Biotecnol Cellulari & Ematol, Policlin Umberto I, I-00161 Rome, Italy

来源：

RESEARCH IN MICROBIOLOGY | 2009年 / 160卷 / 07期

关键词：

Universal common ancestor; Domains of life; Translation initiation factors; mRNA structure; Initiator tRNA; PROKARYOTIC PROTEIN-SYNTHESIS; TRANSFER-RNA METHIONINE; ARCHAEON SULFOLOBUS-SOLFATARICUS; LEADERLESS MESSENGER-RNA; FACTOR IF2; NUCLEOTIDE-SEQUENCE; FUNCTIONAL-ANALYSIS; ALPHA-SUBUNIT; GAMMA-SUBUNIT; BETA-SUBUNIT;

D O I：

10.1016/j.resmic.2009.06.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Initiation of protein synthesis, entailing ribosomal recognition of the mRNA start codon and setting of the correct reading frame, is the rate-limiting step in translation and the main target of translation regulation in all modern cells. As efficient selection of the translation start site is vital for survival of extant cells, a mechanism for ensuring this may already have been in existence in the last universal common ancestor of present-day cells. This article reviews known features of the molecular machinery for initiation in the primary domains of life, Bacteria, Archaea and Eukarya, and attempts to identify conserved features that may be useful for reconstructing a model of the ancestral initiation apparatus. (C) 2009 Elsevier Masson SAS. All fights reserved.

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页码：493 / 501

页数：9

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