Relationship between mRNA stability and intron presence

被引：59

作者：

Wang, Hai-Fang ^{[1
]}

Feng, Liang ^{[1
]}

Niu, Deng-Ke ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Life Sci, Minist Educ, Key Lab Biodivers Sci & Ecol Engn, Beijing 100875, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 354卷 / 01期

基金：

中国国家自然科学基金;

关键词：

mRNA decay rate; mRNA half-life; intron presence; intron abundance; gene ontology;

D O I：

10.1016/j.bbrc.2006.12.184

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Introns were found to enhance almost every steps of gene expression except increasing mRNA stability. By analyzing the genome-wide data of mRNA stability published by someone previously, we found that human intron-containing genes have more stable mRNAs than intronless genes, and the Arabidopsis thaliana genes with the most unstable mRNAs have fewer introns than other genes in the genome. After controlling for mRNA length, we found mRNA stability is still positively correlated with intron number in human intron-containing genes. But in yeast Saccharomyces cerevisiae, two different datasets on mRNA half-life gave conflicting results. The components of messenger ribonucleoprotein particles recruited during intron splicing may be retained in cytoplasmic mRNPs and act as signals of mRNA stability or simply insulators to avoid mRNA degradation. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：203 / 208

页数：6

共 34 条

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