mTOR signaling at a glance

被引：1895

作者：

Laplante, Mathieu ^{[1
,2
]}

Sabatini, David M. ^{[1
,2
,3
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[3] MIT, Koch Ctr Integrat Canc Res, Cambridge, MA 02139 USA

来源：

JOURNAL OF CELL SCIENCE | 2009年 / 122卷 / 20期

关键词：

TUBEROUS SCLEROSIS COMPLEX; MESSENGER-RNA TRANSLATION; TUMOR-SUPPRESSOR COMPLEX; IKK-BETA SUPPRESSION; MAMMALIAN TARGET; CELL-GROWTH; AMINO-ACIDS; BINDING PARTNER; PROTEIN-KINASE; RAPAMYCIN MTOR;

D O I：

10.1242/jcs.051011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

[No abstract available]

引用

页码：3589 / 3594

页数：6

共 70 条

[1]

A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets [J].

Arsham, AM ;

Howell, JJ ;

Simon, MC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (32) :29655-29660

[2]

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy [J].

Bentzinger, C. Florian ;

Romanino, Klaas ;

Cloetta, Dimitri ;

Lin, Shuo ;

Mascarenhas, Joseph B. ;

Oliveri, Filippo ;

Xia, Jinyu ;

Casanova, Emilio ;

Costa, Celine F. ;

Brink, Marijke ;

Zorzato, Francesco ;

Hall, Michael N. ;

Rueegg, Markus A. .

CELL METABOLISM, 2008, 8 (05) :411-424

[3]

PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR [J].

Bernardi, Rosa ;

Guernah, Ilhem ;

Jin, David ;

Grisendi, Silvia ;

Alimonti, Andrea ;

Teruya-Feldstein, Julie ;

Cordon-Cardo, Carlos ;

Simon, M. Celeste ;

Rafii, Shahin ;

Pandolfi, Pier Paolo .

NATURE, 2006, 442 (7104) :779-785

[4]

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex [J].

Brugarolas, J ;

Lei, K ;

Hurley, RL ;

Manning, BD ;

Reiling, JH ;

Hafen, E ;

Witter, LA ;

Ellisen, LW ;

Kaelin, WG .

GENES & DEVELOPMENT, 2004, 18 (23) :2893-2904

[5]

The FoxO code [J].

Calnan, D. R. ;

Brunet, A. .

ONCOGENE, 2008, 27 (16) :2276-2288

[6]

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species [J].

Chen, Chong ;

Liu, Yu ;

Liu, Runhua ;

Ikenoue, Tsuneo ;

Guan, Kun-Liang ;

Liu, Yang ;

Zheng, Pan .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (10) :2397-2408

[7]

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation [J].

Choo, Andrew Y. ;

Yoon, Sang-Oh ;

Kim, Sang Gyun ;

Roux, Philippe P. ;

Blenis, John .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (45) :17414-17419

[8]

Autophagy and signaling: their role in cell survival and cell death [J].

Codogno, P ;

Meijer, AJ .

CELL DEATH AND DIFFERENTIATION, 2005, 12 (Suppl 2) :1509-1518

[9]

The tuberous sclerosis complex [J].

Crino, Peter B. ;

Nathanson, Katherine L. ;

Henske, Elizabeth Petri .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (13) :1345-1356

[10]

mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex [J].

Cunningham, John T. ;

Rodgers, Joseph T. ;

Arlow, Daniel H. ;

Vazquez, Francisca ;

Mootha, Vamsi K. ;

Puigserver, Pere .

NATURE, 2007, 450 (7170) :736-U12

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