Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle

被引：378

作者：

Mecocci, P

Fanó, G

Fulle, S

MacGarvey, U

Shinobu, L

Polidori, MC

Cherubini, A

Vecchiet, J

Senin, U

Beal, MF

机构：

[1] Massachusetts Gen Hosp, Neurol Serv, Boston, MA 02114 USA

[2] Harvard Med Sch, Boston, MA USA

[3] Univ Perugia, Ist Gerontol & Geriatria, Perugia, Italy

[4] Univ G DAnnunzio, Dipartimento Sci Biomed, Chieti, Italy

[5] Univ Perugia, Dipartimento Biol Cellulare & Mol, I-06100 Perugia, Italy

[6] Univ G DAnnunzio, Ist Malattie Infett, Chieti, Italy

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1999年 / 26卷 / 3-4期

关键词：

aging; muscle oxidative damage; 8-hydroxy-2-deoxyguanosine; malondialdehyde; protein carbonyls; free radicals;

D O I：

10.1016/S0891-5849(98)00208-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A role for oxidative damage in normal aging is supported by studies in experimental animals, but there is limited evidence in man. We examined markers of oxidative damage to DNA, Lipids, and proteins in 66 muscle biopsy specimens from humans aged 25 to 93 years. There were age-dependent increases in 8-hydroxy-2-deoxyguanosine (OH(8)dG), a marker of oxidative damage to DNA, in malondialdehyde (MDA), a marker of lipid peroxidation, and to a lesser extent in protein carbonyl groups, a marker of protein oxidation. The increases in OH(8)dG were significantly correlated with increases in MDA. These results provide evidence for a role of oxidative damage in human aging which may contribute to age-dependent losses of muscle strength and stamina. (C) 1998 Elsevier Science Inc.

引用

页码：303 / 308

页数：6

共 41 条

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