Asia-Pacific consensus guidelines on gastric cancer prevention

被引：261

作者：

Fock, Kwong Ming ^{[1
]}

Talley, Nick ^{[2
]}

Moayyedi, Paul ^{[3
]}

Hunt, Richard ^{[3
]}

Azuma, Takeshi ^{[4
]}

Sugano, Kentaro ^{[5
]}

Xiao, Shu Dong ^{[8
]}

Lam, Shiu Kum ^{[9
]}

Goh, Khean Lee ^{[10
]}

Chiba, Tsutomu ^{[6
]}

Uemura, Naomi ^{[7
]}

Kim, Jae G. ^{[11
]}

Kim, Nayoung ^{[12
]}

Ang, Tiing Leong ^{[1
]}

Mahachai, Varocha ^{[13
]}

Mitchell, Hazel ^{[15
]}

Rani, Abdul Aziz ^{[16
]}

Liou, Jyh Ming ^{[17
]}

Vilaichone, Ratha-Korn ^{[14
]}

Sollano, Jose ^{[18
]}

机构：

[1] Changi Gen Hosp, Dept Med, Div Gastroenterol, Singapore 529889, Singapore

[2] Mayo Clin, Coll Med, Rochester, MN USA

[3] McMaster Univ, Med Ctr, Hamilton, ON L8S 4L8, Canada

[4] Univ Fukui, Fukui 910, Japan

[5] Jichi Med Univ, Jichi, Tochigi, Japan

[6] Kyoto Univ, Kyoto, Japan

[7] Kure Kyousai Gen Hosp, Kure, Japan

[8] Shanghai Inst Digest Dis, Shanghai, Peoples R China

[9] Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China

[10] Univ Malaya, Kuala Lumpur, Malaysia

[11] Chung Ang Univ, Coll Med, Seoul 156756, South Korea

[12] Seoul Natl Univ, Coll Med, Seoul, South Korea

[13] Chulalongkorn Univ Hosp, Bangkok, Thailand

[14] Thammasat Univ Hosp, Pathum Thani, Thailand

[15] Univ New S Wales, Sydney, NSW, Australia

[16] Univ Indonesia, Jakarta, Indonesia

[17] Natl Taiwan Univ Hosp, Taipei, Taiwan

[18] Univ Santo Tomas, Manila, Philippines

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2008年 / 23卷 / 03期

关键词：

gastric cancer; guidelines; Helicobacter pylori; prevention;

D O I：

10.1111/j.1440-1746.2008.05314.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background and Aim: Gastric cancer is a major health burden in the Asia-Pacific region but consensus on prevention strategies has been lacking. We aimed to critically evaluate strategies for preventing gastric cancer. Methods: A multidisciplinary group developed consensus statements using a Delphi approach. Relevant data were presented, and the quality of evidence, strength of recommendation, and level of consensus were graded. Results: Helicobacter pylori infection is a necessary but not sufficient causal factor for non-cardia gastric adenocarcinoma. A high intake of salt is strongly associated with gastric cancer. Fresh fruits and vegetables are protective but the use of vitamins and other dietary supplements does not prevent gastric cancer. Host-bacterial interaction in H. pylori infection results in different patterns of gastritis and differences in gastric acid secretion which determine disease outcome. A positive family history of gastric cancer is an important risk factor. Low serum pepsinogens reflect gastric atrophy and may be useful as a marker to identify populations at high risk for gastric cancer. H. pylori screening and treatment is a recommended gastric cancer risk reduction strategy in high-risk populations. H. pylori screening and treatment is most effective before atrophic gastritis has developed. It does not exclude the existing practice of gastric cancer surveillance in high-risk populations. In populations at low risk for gastric cancer, H. pylori screening is not recommended. First-line treatment of H. pylori infection should be in accordance with national treatment guidelines. Conclusion: A strategy of H. pylori screening and eradication in high-risk populations will probably reduce gastric cancer incidence, and based on current evidence is recommended by consensus.

引用

页码：351 / 365

页数：15

共 141 条

[1]

Ahmad M M, 1997, J Epidemiol, V7, P251

[2]

Aldana LP, 2002, HELICOBACTER, V7, P306

[3] Racial differences in Helicobacter pylori, serum pepsinogen and gastric cancer incidence in an urban Asian population [J].

Ang, TL ;

Fock, KM ;

Dhamodaran, S ;

Teo, EK ;

Tan, J .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2005, 20 (10) :1603-1609

[4]

[Anonymous], 2004, COCHRANE DATABASE SY

[5] Circulating anti-Helicobacter pylori immunoglobulin A antibodies and low serum pepsinogen I level are associated with increased risk of gastric cancer [J].

Aromaa, A ;

Kosunen, TU ;

Knekt, P ;

Maatela, J ;

Teppo, L ;

Heinonen, OP ;

Harkonen, M ;

Hakama, MK .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1996, 144 (02) :142-149

[6] Association between diversity in the Src homology 2 domain-containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer [J].

Azuma, T ;

Yamazaki, S ;

Yamakawa, A ;

Ohtani, M ;

Muramatsu, A ;

Suto, H ;

Ito, Y ;

Dojo, M ;

Yamazaki, Y ;

Kuriyama, M ;

Keida, Y ;

Higashi, H ;

Hatakeyama, M .

JOURNAL OF INFECTIOUS DISEASES, 2004, 189 (05) :820-827

[7]

BERRINO F, 1999, IARC SCI PUBLICATION, V151

[8] Variation in serum pepsinogens with severity and topography of Helicobacter pylori-associated chronic gastritis in dyspeptic patients referred for endoscopy [J].

Bodger, K ;

Wyatt, JI ;

Heatley, RV .

HELICOBACTER, 2001, 6 (03) :216-224

[9] Will treatment of Helicobacter pylori infection in childhood alter the risk of developing gastric cancer? [J].

Bourke, B .

CANADIAN JOURNAL OF GASTROENTEROLOGY, 2005, 19 (07) :409-411

[10]

Brenner H, 2000, CANCER, V88, P274, DOI 10.1002/(SICI)1097-0142(20000115)88:2<274::AID-CNCR5>3.0.CO

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