Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells

被引:350
作者
Pepper, Marion [1 ]
Pagan, Antonio J. [1 ]
Igyarto, Botond Z. [2 ]
Taylor, Justin J. [1 ]
Jenkins, Marc K. [1 ]
机构
[1] Univ Minnesota, Sch Med, Dept Microbiol, Ctr Immunol, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Sch Med, Dept Dermatol, Ctr Immunol, Minneapolis, MN 55455 USA
关键词
CD4; T-CELLS; LISTERIA-MONOCYTOGENES INFECTION; FOLLICULAR HELPER-CELL; IN-VIVO; B-CELLS; IMMUNE-RESPONSES; STAT PROTEINS; LYMPH-NODES; DIFFERENTIATION; EXPRESSION;
D O I
10.1016/j.immuni.2011.09.009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Listeria monocyto genes infection generates T helper 1 (Th1) effector memory cells and CC chemokine receptor 7 (CCR7)(+) cells resembling central memory cells. We tracked endogenous L. monocytogenes-specific CD4(+) T cells to determine how these memory cells are formed. Two effector cell populations were already present several days after infection. One highly expressed the T-bet transcription factor and produced Th1 memory cells in an interleukin-2 (IL-2) receptor-dependent fashion. The other resided in the T cell areas, expressed CCR7 and CXC chemokine receptor 5 (CXCR5), and like follicular helper cells depended on the Bcl6 transcription factor and inducible costimulator ligand on B cells. The CCR7(+)CXCR5(+) effector cells produced similar memory cells that generated diverse effector cell populations in a secondary response. Thus, Th1 effector memory and follicular helper-like central memory cells are produced from early effector cell populations that diverge in response to signals from the IL-2 receptor, Bcl6, and B cells.
引用
收藏
页码:583 / 595
页数:13
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