International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

被引：110

作者：

Back, Magnus ^{[1
,2
]}

Dahlen, Sven-Erik ^{[3
]}

Drazen, Jeffrey M. ^{[4
]}

Evans, Jilly F. ^{[5
]}

Serhan, Charles N. ^{[6
]}

Shimizu, Takao ^{[7
]}

Yokomizo, Takehiko ^{[8
]}

Rovati, G. Enrico ^{[9
]}

机构：

[1] Karolinska Univ Hosp, Ctr Mol Med, Dept Cardiol, S-17176 Stockholm, Sweden

[2] Karolinska Inst, Dept Med, Stockholm, Sweden

[3] Karolinska Inst, Div Physiol, Natl Inst Environm Med, Stockholm, Sweden

[4] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA

[5] Amira Pharmaceut Inc, San Diego, CA USA

[6] Brigham & Womens Hosp, Ctr Expt Therapeut & Reperfus Injury, Boston, MA 02115 USA

[7] Univ Tokyo, Fac Med, Dept Biochem & Mol Biol, Bunkyo Ku, Tokyo 113, Japan

[8] Kyushu Univ, Dept Med Biochem, Fukuoka 812, Japan

[9] Univ Milan, Dept Pharmacol Sci, Mol Pharmacol Lab, Milan, Italy

来源：

PHARMACOLOGICAL REVIEWS | 2011年 / 63卷 / 03期

关键词：

INTESTINAL EPITHELIAL-CELLS; SEASONAL ALLERGIC RHINITIS; PROTEIN-COUPLED RECEPTORS; SMOOTH-MUSCLE-CELLS; PLACEBO-CONTROLLED TRIAL; HUMAN-ENDOTHELIAL-CELLS; ASPIRIN-INDUCED ASTHMA; TUMOR-NECROSIS-FACTOR; KAPPA-B ACTIVATION; HUMAN MAST-CELLS;

D O I：

10.1124/pr.110.004184

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The seven-transmembrane G protein-coupled receptors activated by leukotrienes are divided into two subclasses based on their ligand specificity for either leukotriene B-4 or the cysteinyl leukotrienes (LTC4, LTD4, and LTE4). These receptors have been designated BLT and CysLT receptors, respectively, and a subdivision into BLT1 and BLT2 receptors and CysLT(1) and CysLT(2) receptors has been established. However, recent findings have also indicated the existence of putative additional leukotriene receptor subtypes. Furthermore, other ligands interact with the leukotriene receptors. Finally, leukotrienes may also activate other receptor classes, such as purinergic receptors. The aim of this review is to provide an update on the pharmacology, expression patterns, and pathophysiological roles of the leukotriene receptors as well as the therapeutic developments in this area of research.

引用

页码：539 / 584

页数：46

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