Notch signalling pathway in tooth development and adult dental cells

被引：47

作者：

Cai, X. ^{[1
]}

Gong, P. ^{[1
]}

Huang, Y. ^{[2
]}

Lin, Y. ^{[1
]}

机构：

[1] Sichuan Univ, W China Coll Stomatol, State Key Lab Oral Dis, Chengdu 610064, Peoples R China

[2] Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China

来源：

CELL PROLIFERATION | 2011年 / 44卷 / 06期

基金：

中国国家自然科学基金;

关键词：

EPITHELIAL-MESENCHYMAL INTERACTIONS; DEVELOPING MOUSE TOOTH; NF-KAPPA-B; SIDE POPULATION CELLS; RBP-J-KAPPA; BONE MORPHOGENETIC PROTEIN-2; PULP STEM-CELLS; MAMMALIAN TOOTH; IN-VITRO; INTRACELLULAR DOMAIN;

D O I：

10.1111/j.1365-2184.2011.00780.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Notch signalling is a highly conserved intercellular signal transfer mechanism that includes canonical and non-canonical pathways. It regulates differentiation and proliferation of stem/progenitor cells by means of para-inducing effects. Expression and activation of Notch signalling factors (receptors and ligands) are critical not only for development of the dental germ but also for regeneration of injured tissue associated with mature teeth. Notch signalling plays key roles in differentiation of odontoblasts and osteoblasts, calcification of tooth hard tissue, formation of cusp patterns and generation of tooth roots. After tooth eruption, Notch signalling can also be triggered in dental stem cells of the pulp, where it induces them to differentiate into odontoblasts, thus generating fresh dentine tissue. Other signalling pathways, such as TGF beta, NF-kappa B, Wnt, Fgf and Shh also interact with Notch signalling during tooth development.

引用

页码：495 / 507

页数：13

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