Small-molecule diversification from iterated branching reaction pathways enabled by DNA-templated synthesis

被引：17

作者：

Calderone, CT ^{[1
]}

Liu, DR ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 45期

关键词：

bioorganic chemistry; combinatorial chemistry; diversity-oriented synthesis; DNA; template synthesis;

D O I：

10.1002/anie.200502899

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Two unique features of DNA-templated synthesis were integrated to prepare complex small molecules by using iterated branching reaction pathways: the direction of multiple, otherwise "incompatible", reaction types in one reaction vessel and the direction of sequence-programmed subsets of reaction intermediates to appropriate reagents. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7383 / 7386

页数：4

共 25 条

[1] THE COMBINATORIAL SYNTHESIS AND CHEMICAL AND BIOLOGICAL EVALUATION OF A 1,4-BENZODIAZEPINE LIBRARY [J].

BUNIN, BA ;

PLUNKETT, MJ ;

ELLMAN, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :4708-4712

[2]

Burke M. D., 2004, ANGEW CHEM, V116, P48

[3] Generating diverse skeletons of small molecules combinatorially [J].

Burke, MD ;

Berger, EM ;

Schreiber, SL .

SCIENCE, 2003, 302 (5645) :613-618

[4] A synthesis strategy yielding skeletally diverse small molecules combinatorially [J].

Burke, MD ;

Berger, EM ;

Schreiber, SL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (43) :14095-14104

[5]

Calderone CT, 2002, ANGEW CHEM INT EDIT, V41, P4104, DOI 10.1002/1521-3773(20021104)41:21<4104::AID-ANIE4104>3.0.CO

[6]

2-O

[7] A combinatorial scaffold approach toward kinase-directed heterocycle libraries [J].

Ding, S ;

Gray, NS ;

Wu, X ;

Ding, Q ;

Schultz, PG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (08) :1594-1596

[8] Highly sensitive in vitro selections for DNA-linked synthetic small molecules with protein binding affinity and specificity [J].

Doyon, JB ;

Snyder, TM ;

Liu, DR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (41) :12372-12373

[9] GENERAL-METHOD FOR RAPID SYNTHESIS OF MULTICOMPONENT PEPTIDE MIXTURES [J].

FURKA, A ;

SEBESTYEN, F ;

ASGEDOM, M ;

DIBO, G .

INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1991, 37 (06) :487-493

[10]

Gartner Z. J., 2002, ANGEW CHEM, V114, P1874

← 1 2 3 →