In vivo Na-23 NMR studies of myotonic dystrophy

被引：29

作者：

Kushnir, T

Knubovets, T

Itzchak, Y

Eliav, U

Sadeh, M

Rapoport, L

Kott, E

Navon, G

机构：

[1] TEL AVIV UNIV,SCH CHEM,CHAIM SHEBA MED CTR,DEPT NEUROL,IL-52621 TEL AVIV,ISRAEL

[2] SAPIR MED CTR,DEPT NEUROL,KEFAR SAVA,ISRAEL

来源：

MAGNETIC RESONANCE IN MEDICINE | 1997年 / 37卷 / 02期

关键词：

myotonic dystrophy; Na-23; NMR; triple quantum-filtered spectroscopy;

D O I：

10.1002/mrm.1910370209

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Myotonic dystrophy is an inherited multi-system disease. Its pathophysiology leading to muscle malfunction and damage is not well understood. Na-23 NMR spectroscopy was applied here for an in vivo comparative study of the calf muscles of 7 myotonic dystrophy patients at various stages of the disease and 11 healthy volunteers. Both the total sodium content, expressed as the ratio of the Na-23 and H-1 water signals, and the fast transverse relaxation time, T-2f, determined from the triple quantum-filtered spectra, increased in correlation with the severity of the disease. The results demonstrate that Na-23 NMR enables the quantitation of myotonic dystrophy progression.

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页码：192 / 196

页数：5

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