In vitro activities of 10 antifungal drugs against 508 dermatophyte strains

被引:137
作者
Fernández-Torres, B
Carrillo, AJ
Martín, E
Del Palacio, A
Moore, MK
Valverde, A
Serrano, M
Guarro, J
机构
[1] Univ Rovira & Virgili, Unitat Microbiol, Fac Med, Inst Estudis Avancats, E-43201 Reus, Spain
[2] Hosp Valme, Seville, Spain
[3] Asesoria Cientif & Invest Aplicada, Dept Microbiol, Barcelona, Spain
[4] Hosp 12 Octubre, Madrid, Spain
[5] St Thomas Hosp, London, England
关键词
D O I
10.1128/AAC.45.9.2524-2528.2001
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We have tested 508 strains belonging to 24 species of dermatophytes against 10 antifungal drugs following mainly the NCCLS (M38-P) standard for filamentous fungi. However, several important factors, such as the temperature (28 versus 35 degreesC) and time of incubation (4 to 10 days versus 21 to 74 h), have been modified. The antifungals used were itraconazole, ketoconazole, miconazole, clotrimazole, voriconazole, terbinafine, amphotericin B, fluconazole, UR-9825, and G-1. In general, with the exception of fluconazole and G-1, all antifungals were shown to be highly effective.
引用
收藏
页码:2524 / 2528
页数:5
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