Glomerular filtration rate in early diabetes: ongoing discussions of causes and mechanisms

被引：13

作者：

Frische, Sebastian ^{[1
]}

机构：

[1] Aarhus Univ, Inst Anat, Water & Salt Res Ctr, DK-8000 Aarhus C, Denmark

来源：

JOURNAL OF NEPHROLOGY | 2011年 / 24卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

Carbohydrate; Diabetes; Diet; GFR; NaCl; RENAL HEMODYNAMICS; SODIUM RESTRICTION; SALT; HYPERFILTRATION; MELLITUS; KIDNEY; REABSORPTION;

D O I：

10.5301/jn.5000009

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Glomerular hyperfiltration (>140 ml/min per 1.73 m(2) body surface area) is found in early diabetes and is associated with a poor prognosis with respect to the development of diabetic kidney disease. This review addresses recent investigations and discussions of the following hypotheses behind diabetic hyperfiltration: Increased proximal tubular volume reabsorption results in a pressure drop in Bowman's capsule which increases glomerular filtration rate (GFR). Proximal tubular hyperreabsorption induces an increase in GFR mediated by tubuloglomerular feedback. Dietary NaCl restriction results in a paradoxically increased GFR and increased urine volume in diabetic animals.

引用

页码：537 / 540

页数：4

共 19 条

[1] Salt restriction reduces hyperfiltration, renal enlargement, and albuminuria in experimental diabetes [J].

Allen, TJ ;

Waldron, MJ ;

Casley, D ;

Jerums, G ;

Cooper, ME .

DIABETES, 1997, 46 (01) :119-124

[2] PROGRESSIVE INCREASES IN LUMINAL GLUCOSE STIMULATE PROXIMAL SODIUM-ABSORPTION IN NORMAL AND DIABETIC RATS [J].

BANK, N ;

AYNEDJIAN, HS .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (01) :309-316

[3] SODIUM RESTRICTION CORRECTS HYPERFILTRATION OF DIABETES [J].

BANK, N ;

LAHORRA, MAG ;

AYNEDJIAN, HS ;

WILKES, BM .

AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 254 (05) :F668-F676

[4] The salt paradox of the early diabetic kidney is independent of renal innervation [J].

Birk, C ;

Richter, K ;

Huang, DY ;

Piesch, C ;

Luippold, G ;

Vallon, V .

KIDNEY & BLOOD PRESSURE RESEARCH, 2003, 26 (5-6) :344-350

[5]

BROCHNERMORTENSEN J, 1984, DIABETOLOGIA, V27, P189

[6] Lack of A1 adenosine receptors augments diabetic hyperfiltration and glomerular injury [J].

Faulhaber-Walter, Robert ;

Chen, Limeng ;

Oppermann, Mona ;

Kim, Soo Mi ;

Huang, Yuning ;

Hiramatsu, Noriyuki ;

Mizel, Diane ;

Kajiyama, Hiroshi ;

Zerfas, Patricia ;

Briggs, Josephine P. ;

Kopp, Jeffrey B. ;

Schnermann, Jurgen .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2008, 19 (04) :722-730

[7] Salt-resistant blood pressure and salt-sensitive renal autoregulation in chronic streptozotocin diabetes [J].

Lau, Catherine ;

Sudbury, Ian ;

Thomson, Michael ;

Howard, Perry L. ;

Magil, Alex B. ;

Cupples, William A. .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2009, 296 (06) :R1761-R1770

[8]

Miller JA, 1997, J AM SOC NEPHROL, V8, P749

[9] Twelve shifting paradigms in diabetic renal disease and hypertension [J].

Mogensen, Carl Erik .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2008, 82 :S2-S9

[10] Opposing effects of NaCl restriction and carbohydrate loading on urine volume in diabetic rats [J].

O'Neill, H. A. ;

Kwon, T-H. ;

Ring, T. ;

Dimke, H. ;

Lebeck, J. ;

Frokiaer, J. ;

Collins, P. B. ;

Nielsen, S. ;

Frische, S. .

ACTA PHYSIOLOGICA, 2011, 202 (01) :47-57

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