Disruption of protein-protein interactions:: Towards new targets for chemotherapy

被引：89

作者：

Loregian, A ^{[1
]}

Palú, G ^{[1
]}

机构：

[1] Univ Padua, Dept Histol Microbiol & Med Biotechnol, I-35121 Padua, Italy

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2005年 / 204卷 / 03期

关键词：

D O I：

10.1002/jcp.20356

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Protein-protein interactions play a key role in various mechanisms of cellular-growth and differentiation, and in the replication of pathogen organisms in hostcells. Thus, inhibition of these interactionsisa promisingnovel approach for rational drug design against a wide number of cellular and microbial targets. In the past few years, attempts to inhibit protein-protein interactions using antibodies, peptides, and synthetic or natural small molecules have met with varying degrees of success, and these will be the focus of this review.

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页码：750 / 762

页数：13

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