Effects of resistance and aerobic exercise on physical function, bone mineral density, OPG and RANKL in older women

被引:139
作者
Marques, Elisa A. [1 ]
Wanderley, Flavia [1 ]
Machado, Leandro [2 ]
Sousa, Filipa [2 ]
Viana, Joao L. [4 ]
Moreira-Goncalves, Daniel [1 ]
Moreira, Pedro [1 ,3 ]
Mota, Jorge [1 ]
Carvalho, Joana [1 ]
机构
[1] Univ Porto, Res Ctr Phys Act Hlth & Leisure, Fac Sport Sci, P-4200450 Oporto, Portugal
[2] Univ Porto, Ctr Res Educ Innovat & Intervent Sport, Fac Sport Sci, P-4200450 Oporto, Portugal
[3] Univ Porto, Fac Nutr & Food Sci, P-4200465 Oporto, Portugal
[4] Univ Loughborough, Sch Sport Exercise & Hlth Sci, Loughborough, Leics, England
关键词
Bone mass; Fall risk; Exercise; Age; Biomarkers; RECEPTOR ACTIVATOR; SERUM OSTEOPROTEGERIN; OSTEOCLAST DIFFERENTIATION; MUSCLE STRENGTH; TRABECULAR BONE; WEIGHT-LOSS; BALANCE; ADULTS; MASS; TURNOVER;
D O I
10.1016/j.exger.2011.02.005
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
030301 [社会学]; 100201 [内科学];
摘要
This study compared the effects of a resistance training protocol and a moderate-impact aerobic training protocol on bone mineral density (BMD), physical ability, serum osteoprotegerin (OPG), and receptor activator of nuclear factor kappa B ligand (RANKL) levels. Seventy-one older women were randomly assigned to resistance exercise (RE), aerobic exercise (AE) or a control group (CON). Both interventions were conducted 3 times per week for 8 months. Outcome measures included proximal femur BMD, muscle strength, balance, body composition, serum OPG, and RANKL levels. Potential confounding variables included dietary intake, accelerometer-based physical activity (PA), and molecularly defined lactase nonpersistence. After 8 months, only RE group exhibited increases in BMD at the trochanter (2.9%) and total hip (1.5%), and improved body composition. Both RE and AE groups improved balance. No significant changes were observed in OPG and RANKL levels, and OPG/RANKL ratio. Lactase nonpersistence was not associated with BMD changes. No group differences were observed in baseline values or change in dietary intakes and daily PA. Data suggest that 8 months of RE may be more effective than AE for inducing favourable changes in BMD and muscle strength, whilst both interventions demonstrate to protect against the functional balance control that is strongly related to fall risk. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:524 / 532
页数:9
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