Relation of heart rate at rest and mortality in the women's health and aging study

被引:35
作者
Chang, M
Havlik, RJ
Corti, MC
Chaves, PHM
Fried, LP
Guralnik, JM
机构
[1] NIA, Lab Epidemiol Demog & Biometry, NIH, Bethesda, MD 20892 USA
[2] Osped camposampiero, Dept Geriatr, Local Hlth Unit 15, Padua, Italy
[3] Johns Hopkins Med Inst, Dept Med, Baltimore, MD 21205 USA
[4] Johns Hopkins Med Inst, Dept Epidemiol, Baltimore, MD 21205 USA
[5] Johns Hopkins Ctr Aging & Hlth, Baltimore, MD USA
关键词
D O I
10.1016/j.amjcard.2003.08.010
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Increased heart rate (HR) has been shown to be associated with increased risk of all-cause and heart disease mortality. However, HR as a health indicator in disabled older women has not been closely examined. The purpose of this study is to assess the association between HR and 3-year mortality in disabled older women. HR at rest was measured using the electrocardiogram. Three groups were categorized by baseline HR (beats per minute): (1) <60, (2) 60 to 89, and (3) greater than or equal to90. The survival rate over 3 years was examined. For the total population, age-adjusted 3-year mortality was nearly 40% for the HR greater than or equal to90 group, compared with <20% mortality in the HR 60 to 89 group. Women with a HR <60 beats/min had similar mortality to those with HRs 60 to 89 beats/min. Among women with no heart disease and normal electrocardiograms, mortality was slightly lower in all groups, but the association of elevated HR with increased mortality remained. In Cox proportional hazard models, after adjustment for age, number of diseases, medications, blood pressure, smoking status, body mass index, ankle-brachial index, activity status, physical performance score, and forced expiratory volume in the first second, there remained a twofold increase in the,risk of death for the HR :90 group. Subclinical conditions not measured in this study, such as mild heart failure, may be associated with both increased HR and mortality; this may explain the relation. In patients with and without heart disease, further investigation, of cardiovascular status may be warranted if their HR is 2:90 beats/min. (C) 2003 by Excerpta Medica, Inc.
引用
收藏
页码:1294 / 1299
页数:6
相关论文
共 29 条
[1]   THE ROLE OF SYMPATHETIC ACTIVITY IN ATHEROGENESIS - EFFECTS OF BETA-BLOCKADE [J].
ABLAD, B ;
BJORKMAN, JA ;
GUSTAFSSON, D ;
HANSSON, G ;
OSTLUNDLINDQVIST, AM ;
PETTERSSON, K .
AMERICAN HEART JOURNAL, 1988, 116 (01) :322-327
[2]  
[Anonymous], J GERONTOL
[3]   HEMODYNAMIC STRESS AND EXPERIMENTAL AORTOILIAC ATHEROSCLEROSIS [J].
BASSIOUNY, HS ;
ZARINS, CK ;
KADOWAKI, MH ;
GLAGOV, S .
JOURNAL OF VASCULAR SURGERY, 1994, 19 (03) :426-434
[4]   Influence of heart rate on mortality in a French population - Role of age, gender, and blood pressure [J].
Benetos, A ;
Rudnichi, A ;
Thomas, F ;
Safar, M ;
Guize, L .
HYPERTENSION, 1999, 33 (01) :44-52
[5]   Association between high heart rate and high arterial rigidity in normotensive and hypertensive subjects [J].
Cunha, RS ;
Pannier, B ;
Benetos, A ;
Siche, JP ;
London, GM ;
Mallion, JM ;
Safar, ME .
JOURNAL OF HYPERTENSION, 1997, 15 (12) :1423-1430
[6]   Measurement of venous blood flow in the human fetus: a dream comes true, but now for some standardization [J].
Ferrazzi, E .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2001, 18 (01) :1-4
[7]  
FRIED L, 1998, JAMA-J AM MED ASSOC, V25, P585
[8]   Heart rate and mortality in a Japanese general population: An 18-year follow-up study [J].
Fujiura, Y ;
Adachi, H ;
Tsuruta, M ;
Jacobs, DR ;
Hirai, Y ;
Imaizumi, T .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 2001, 54 (05) :495-500
[9]  
GILLUM RF, 1992, PUBLIC HEALTH REP, V107, P193
[10]  
Guralnik J.M., 1995, The women's health and aging study: Health and social characteristics of older women with disability