A model route toward the synthesis of conformationally constrained polyhydroxylated dipeptides from natural carbohydrates

被引：11

作者：

Dondoni, A

Marra, A

Richichi, B

机构：

[1] Univ Ferrara, Chim Organ Lab, Dipartimento Chim, I-44100 Ferrara, Italy

[2] Univ Ferrara, Interdisciplinary Ctr Study Inflammat, I-44100 Ferrara, Italy

来源：

SYNLETT | 2003年 / 15期

关键词：

integrins; peptidomimetics; pyrrolizidinone amino acids; reverse-turn; RGD;

D O I：

10.1055/s-2003-43341

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiopure 6,7-diacetoxy-3-t-butoxycarbonylaminoazabicyclo[3.3.0]octan-2-one-8-carboxylic acid 14 (pyrrolizinone amino acid) was synthesized in 14 steps and 5.8% overall yield from tri-O-benzyl-D-arabinose 5 through the formyl C-iminosugar 9 as a key intermediate.

引用

收藏

页码：2345 / 2348

页数：4

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