Phycomysterols and other sterols from the fungus Phycomyces blakesleeanus

被引：44

作者：

Barrero, AF ^{[1
]}

Oltra, JE ^{[1
]}

Poyatos, JA ^{[1
]}

Jiménez, D ^{[1
]}

Oliver, E ^{[1
]}

机构：

[1] Univ Granada, Fac Ciencias, Dept Quim Organ, Inst Biotechnol, Granada, Spain

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 12期

关键词：

D O I：

10.1021/np980199h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In the search for novel bioactive products from filamentous fungi, sterols and triterpenoids found in Phycomyces blakesleeanus were analyzed using semipreparative HPLC, CC-MS, and NMR techniques. Structures proposed for the three new compounds identified, phycomysterol A (1), phycomysterol B (2), and neoergosterol (3), were confirmed by chemical synthesis. Phycomysterols possess a new natural 19-norergostane skeleton with an aromatic B ring. Phycomysterol A showed anti-HIV activity.

引用

页码：1491 / 1496

页数：6

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