Childhood sexual abuse (CSA) is the form of sexual victimization most correlated with sexual dysfunction in adulthood (Atkeson, Calhoun, Resick, & Ellis, 1994; Sarwer & Durlak, 1996; Laumann, Paik, & Rosen, 1999). The goal of this stud), was to address the sexual ramifications of unresolved CSA and consider The (effectiveness of vasoactive pharmacotherapy,' specifically, sildenafil, for the treatment of women with unresolved CSA. The sample included 35 women (mean age, 45 years) who presented to a sexual health clinic and who were not of childbearing potential. Of the sample 7 women (23%) bad a history of unresolved CSA. Following a psychosexual history, and medical evaluation, all women were treated with 100 mg of sildenafil, to be used over a 6-week period at home. When home doses ti,ere complete, participants filled out the HEI, a valid and reliable 5-item questionnaire asking about sexual response post sildenafil. Parameters of sexual response included vaginal lubrication, amount and quality of sensation, satisfaction with intercourse, and ability to reach orgasm. Trends were calculated comparing women with and without unresolved CSA history, A minority, of women with CSA responded positively to sildenafil.